Process for the production of L-amino acids by fermentation...

Details Process for the production of L-amino acids by fermentation... Process for the production of L-amino acids by fermentation...

2006-05-23

2006-05-23

Kerr, Kathleen (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S115000

Reexamination Certificate

active

07049106

ABSTRACT:
A process for the production of an L-amino acid wherein coryneform bacteria (e.g.Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.

REFERENCES:
patent: 1 038 969 (2000-09-01), None
patent: 1 085 091 (2001-03-01), None
patent: WO 03/029457 (2003-04-01), None
Molenaar et al., “Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle ofCorynebacterium glutamicum”,vol. 182, No. 24, pp. 6884-6891, Dec. 2000.
van der Rest et al., “Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle ofEscherichia coli”, vol. 182, No. 24, pp. 6892-6899, Dec. 2000.
Molenaar et al., “Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) fromCorynebacterium glutamicum”, vol. 254, pp. 395-403, Jan. 1998.

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