Methods and compositions for use in perfusion applications

Details Methods and compositions for use in perfusion applications Methods and compositions for use in perfusion applications

Filed on

2006-01-31

Date issued

2006-01-31

Examiner

Lucchesi, Nicholas D. (Department: 3763)

Patent Class

Surgery

SubClass

Means for introducing or removing material from body for...

SubSubClass

Treating material introduced into or removed from body...

Type

Reexamination Certificate

Status

active

Patent number

06991624

Description

ABSTRACT:
Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.

REFERENCES:
patent: 3677024 (1972-07-01), Segall
patent: 3937821 (1976-02-01), Irikura et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4216205 (1980-08-01), Radowitz
patent: 4663166 (1987-05-01), Veech
patent: 4812310 (1989-03-01), Sato et al.
patent: 4908350 (1990-03-01), Kramer et al.
patent: 4923442 (1990-05-01), Segall et al.
patent: 4927806 (1990-05-01), Kramer et al.
patent: 5082831 (1992-01-01), Leaf et al.
patent: 5084377 (1992-01-01), Rowan et al.
patent: 5130230 (1992-07-01), Segall et al.
patent: RE34077 (1992-09-01), Segall et al.
patent: 5171526 (1992-12-01), Wong et al.
patent: 5210083 (1993-05-01), Pfirrmann
patent: 5274001 (1993-12-01), Borody
patent: 5374624 (1994-12-01), Segel
patent: 5405742 (1995-04-01), Taylor
patent: 5407428 (1995-04-01), Segall et al.
patent: 5514536 (1996-05-01), Taylor
patent: 5574019 (1996-11-01), Segall et al.
patent: 5613944 (1997-03-01), Segall et al.
patent: 5730720 (1998-03-01), Sites et al.
patent: 5968726 (1999-10-01), Segall et al.
patent: 6080538 (2000-06-01), Segall et al.
patent: 6218099 (2001-04-01), Segall et al.
patent: 6589223 (2003-07-01), Segall et al.
Wager, Bertil, et al, “Pharmacological and clinical considerations in selecting crystalloid, colloidal, and oxygen-carrying resuscitation fluids, part 1”,Clinical Pharmacy(1993) vol. 12: 335-346.
Bailes, J.E., et al (Abstract) “The use of ultra-profound hypothermia in a totally exsanguinated and blood substituted canine model 1, the method”,Cyrobiology 27(1990) 662-663.
Elrifaj, J.E. et al, “The use of ultraprofound hypothermia in totally exsanguinated and blood substituted canine model II, the outcome”,Cyrobiology 27(1990) 662-663.
Sternberg, Hal, et al., “Interventive gerontology, cloning, and cyronics, relevance to life extension”,GWUMC Department of Biochemistry Annual Spring Symposia, (1988) 207-219.
Bishop, M.C., et al., “Evaluation of hypertonic citrate flushing solution for kidney preservation using the isolated perfused rat kidney”,Transplantation, (1978) vol. 25, No. 5, 235-239.
Belzer, F.O., et al., “Combination perfusion-cold storage for optimum cadaver kidney function and utilization”,Transplantation, (1985), vol. 39, No. 2, 118-121.
Collins, G.M., “Hypothermic kidney storage”,Transplantation Proceedings(1977), vol. IX, No. 3, 1529-1534.
Segall, P.E., et al., Abstracts, Part I, No. 147,The FASEB Journal, 75thAnnual Meeting, Atlanta, Georgia, Apr. 21-25, (1991).
Waitz, H.D., et al., Abstracts, Part II, No. 4375,The FASEB Journal, 75thAnnual Meeting, Atlanta, Georgia, Apr. 21-25 (1991).
Leavitt, M.L., et al., Abstracts, Part II, No. 4048,The FASEB Journal, 74thAnnual Meeting, Atlanta, Georgia, Apr. 1-5, (1990).
Fischer, Jurgen, et al., “Flush solution 2, a new concept for one to three day hypothermic renal storage preservation”,Transplantation, (1984), vol. 39, No. 2, 122-126.
Kallerhoff, M., et al., “Effects of preservation conditions and temperature on tissue acidification in canine kidneys”,Transplantation, (1985), vol. 39, No. 5, 485-489.
Rosenberg, G.J., “Plasma-substitutes and artificial oxygen carriers”,Proc. 12thCongr. Int. Soc. Blood Transf., Moscow, (1969), Bibl. Haemat., No. 38, Part II, 737-745.
ATCC Catalogue of Bacteria and Bacteriophages, 18thEd., (1992), 486.
Messmer, Konrad, “Characteristics, effects and side-effects of plasma substitutes”, Dept. of Experimental Surgery, University of Heidelberg, 51-70.
Smith, Audrey, “Studies on golden hamsters during cooling to and rewarming from body temperatures below 0° C”,Proceedings of The Royal Society, (1956), Series B, No. 920, vol. 145, 391-442.
Ross, H., et al., “72-hr canine kidney preservation without continuous perfusion”,Transplantation, 1976) vol. 21, No. 6, 498-501.
Spahn, Donat R., et al., “cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions”,Anesth. Analg, (1994), vol. 78, 1000-1021.

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