Anti-allergic complex molecules

Details Anti-allergic complex molecules Anti-allergic complex molecules

2006-09-26

2006-09-26

Weber, John (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C424S185100

Reexamination Certificate

active

07112568

ABSTRACT:
The present invention discloses novel anti-allergic complex molecules, and in particular, peptidic or peptidomimetic molecules, comprising a first part which is competent for cell penetration and a second part which is able to reduce or abolish mast cell degranulation, in particular to reduce or abolish allergy mediators, including histamine secretion from mast cells and protein kinase activation, wherein the first part is connected to the second part via a linker or a direct bond that creates a conformational constraint by forming a bend or turn.

REFERENCES:
patent: 5807746 (1998-09-01), Lin et al.
Aridor et al., “Exocytosis in Mast Cells by Basic Secretagogues: Evidence for Direct Activation of GTP-binding Proteins,” Journal of Cell Biology, vol. 111, pp. 909-917 (1990).
Aridor et al., “Neomycin is a Potent Secretagogue of Mast Cells that Directly Activates a GTP-binding Protein Involved in Exocytosis,” Journal of Cell Biology, vol. 111, pp. 2885-2891 (1990).
Aridor et al., “Activation of Exocytosis by the Heterotrimeric G Protein G13,” Science, vol. 262, pp. 1569-1572 (1993).
Bienenstock et al., “Mast Cell Involvement in Various Inflammatory Processes,” Am Rev Repir Dis 1987; 135:S5-S8.
Chahdi et al., “Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surface,” European Journal of Pharmacology, vol. 341, pp. 329-335 (1998).
Columbo et al., “Substance P Activates the Release of Histamine from Human Skin Mast Cells through a Pertussis Toxin-Sensitive and Protein Kinase C-Dependent Mechanism,” Clinical Immunology and Immunopathology, vol. 81, No. 1, pp. 68-73 (1996).
Devillier et al., “Histamine Release and Local Responses of Rat and Human Skin to Substance P and Other Mammalian Tachykinins,” Pharmacology, vol. 32, pp. 340-347 (1986).
Emadi-Khiav et al., “Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli,” European Journal of Pharmacology, vol. 272, pp. 97-102 (1995).
Ennis et al., “Some Studies on the Release of Histamine From Mast Cells Stimulated with Polylysine,” Br. J Pharmac., vol. 70, pp. 329-334 (1980).
Foreman, “Neuropeptides and the pathogenesis of allergy,” Allergy, vol. 42, pp. 1-11 (1987).
Foreman, “Substance P and Calcitonin Gene-Related Peptide: Effects of Mast Cells and in Human Skin,” Int. Arch. Allergy Appl. Immunol., vol. 82, pp. 366-371 (1987).
Goldberg et al., “Cutaneous responses to histamine, compound 48/80, and codeine in patients with chronic renal failure,” Annals of Allergy, vol. 67. pp. 525-528 (1991).
Gomperts et al., “Intracellular Mechanisms Regulating Exocytotic Secretion in Mast Cells,” Int. Arch. Allergy Appl. Immunol., vol. 94, pp. 38-46 (1991).
Hawiger, “Cellular import of functional peptides to block intracellular signaling,” Curr Opin Immunol., vol. 9, pp. 189-194 (1997).
Kivity et al., “The effect of food and exercise on the skin response to compound 48/80 in patients with food-associated exercise-induced urticaria-angioedema,” J. Allergy Clin. Immunol., vol. 81, pp. 1155-1158 (1988).
Lichtenstein, “Allergy and the Immune System,”, Scientific American, pp. 117-124 (1993).
Lin et al., “Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence,” Journal of Biological Chemistry, vol. 270, pp. 14255-14258 (1995).
Liu et al., “Identification of a functionally important sequence in the cytoplasmic tail of integrin β3by using cell-permeable peptide analogs,” Proc. Natl. Acad. Sci. USA, vol. 93, pp. 11819-11824 (1996).
Mousli et al., “Peptidrgic pathway in human skin and rat peritoneal mast cell activation,” Immunopharmacology, vol. 27, pp. 1-11 (1994).
Pearce et al., “Characteristics of Histamine Secetion Induced by Neuropeptides: Implications for the Relevance of Peptide-Mast Cell Interactions in Allergy and Inflammation,” Int. Arch. Allergy Appl. Immunol., vol. 88, pp. 129-131 (1989).
Prochiantz, “Getting hydrophilic compounds into cells: lessons from homeopeptides,” Curr Opin Neurobiology, vol. 6, pp. 629-634 (1996).
Rojas et al., “Controlling Epidermal Growth Factor (EGF)-stimulated Ras Activation in Intact Cells by a Cell-permeable Peptide Mimicking Phosphorylated EGF Receptor,” Journal of Biological Chemistry, vol. 271, pp. 27456-27461 (1996).
Sagi-Eisenberg, “Signal-Transmission Pathways in Mast Cell Exocytosis,” Immunopharmacology of Mast Cells and Basophils, Academic Press Limited (1993), pp. 71-78.
Sagi-Eisenberg et al., “Structure-Activity Relationship in the Mast Cell Degranulating Capacity of Neurotensin Fragments,” Neuropharmacology, vol. 22, pp. 197-201 (1983).
Shefler et al., “Basic secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and phosphatidylinositol 3-kinase-dependent mechanism,” Eur. J. Immunol., vol. 28, pp. 3468-3478 (1998).
Sussman et al., “Evaluation of Skin Test Response Using Two Techniques of Measurement,” Annals of Allergy, vol. 48, pp. 75-77 (1982).
Theoharides, “The Mast Cell: A Neuroimmunoendocrine Master Player,” Int. J. Tiss. Reac. XVIII(1), pp. 1-21 (1996).

Affiliated with

Also associated with

Rating

Anti-allergic complex molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-allergic complex molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-allergic complex molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3529994