Processes for preparation of sulfonylurea derivatives

Details Processes for preparation of sulfonylurea derivatives Processes for preparation of sulfonylurea derivatives

1995-02-15

1996-06-11

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544321, C07D40112, C07D40312

Patent

active

055257305

ABSTRACT:
The present invention relates to a novel process for preparing sulfonylurea derivatives of formula (I) in a high purity and a high yield characterized in that a sulfonylchloride of formula (V) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII) in the presence of a metal cyanate and an organic base catalyst or a compound of formula (VIII) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII): ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl and R.sup.3 represents hydrogen, methyl, ethyl or phenyl, and to a process for preparing the sulfonylchloride compound of formula (V) above and the compound of formula (VIII) above, both of which are useful as an intermediate compound for preparing the sulfonylurea derivative of formula (I) and to a novel intermediate compound of formula (VIII) as defined above.

REFERENCES:
patent: 4546179 (1985-10-01), Kunz
patent: 4762550 (1988-08-01), Hartzell
patent: 4954164 (1990-09-01), Suzuki et al.
patent: 4956494 (1990-09-01), Husain et al.
patent: 5116405 (1992-05-01), Makino et al.

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