Process for production of optically active amino alcohols

Details Process for production of optically active amino alcohols Process for production of optically active amino alcohols

2006-01-10

2006-01-10

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S491000, C546S334000, C564S337000, C564S357000, C564S358000

Reexamination Certificate

active

06984738

ABSTRACT:
The present invention is to provide a process for producing an optically active amino alcohol which is useful for the synthesis of natural substances and as an intermediate for drugs and agricultural chemicals in a high yield, a high selectivity and an economical manner with a good working efficiency and the present invention relates to a process for producing an optically active amino alcohol represented by the following formula (2)(in the formula, R1is a hydrocarbon group, a substituted hydrocarbon group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R2and R3each independently is hydrogen atom, a hydrocarbon group, a substituted hydrocarbon group, an acyl group, an acyloxy group, an alkyloxycarbonyl group, an aralkyloxycarbonyl group, an aryloxycarbonyl group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R4is hydrogen atom or a protective group; two or more of R1, R2, R3and R4may be bonded each other to form a ring; and * is asymmetric carbon) or a salt thereof which comprises subjecting a compound represented by the following formula (1) or a salt thereof to an asymmetric hydrogenation.(in the formula, R1is a hydrocarbon group, a substituted hydrocarbon group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R2and R3each independently is hydrogen atom, a hydrocarbon group, a substituted hydrocarbon group, an acyl group, an acyloxy group, an alkyloxycarbonyl group, an aralkyloxycarbonyl group, an aryloxycarbonyl group, an aromatic heterocyclic group, a substituted aromatic heterocyclic group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group; R4is hydrogen atom or a protective group; two or more of R1, R2, R3and R4may be bonded each other to form a ring; and a double bond is either cis or trans).

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