Metallic solid supports modified with nucleic acids

Details Metallic solid supports modified with nucleic acids Metallic solid supports modified with nucleic acids

2006-04-25

2006-04-25

Benzion, Gary (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S287200, C436S501000, C536S023100, C536S024300

Reexamination Certificate

active

07033760

ABSTRACT:
The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.

REFERENCES:
patent: 4704193 (1987-11-01), Bowers et al.
patent: 4707352 (1987-11-01), Stavrianopoulos
patent: 4707440 (1987-11-01), Stavrianopoulos
patent: 4711955 (1987-12-01), Ward et al.
patent: 4755458 (1988-07-01), Rabbani et al.
patent: 4787963 (1988-11-01), MacConnell
patent: 4840893 (1989-06-01), Hill et al.
patent: 4849513 (1989-07-01), Smith et al.
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4894325 (1990-01-01), Englehardt et al.
patent: 4943523 (1990-07-01), Stavrianopoulos
patent: 4945045 (1990-07-01), Forrest et al.
patent: 4952685 (1990-08-01), Stavrianopoulos
patent: 4994373 (1991-02-01), Stavrianopoulos et al.
patent: 5002885 (1991-03-01), Stavrianopoulos
patent: 5013831 (1991-05-01), Stavrianopoulos
patent: 5082830 (1992-01-01), Brakel et al.
patent: 5089112 (1992-02-01), Skotheim et al.
patent: 5175269 (1992-12-01), Stavrianopoulos
patent: 5180968 (1993-01-01), Bruckenstein et al.
patent: 5241060 (1993-08-01), Engelhardt et al.
patent: 5242828 (1993-09-01), Bergstrom et al.
patent: 5278043 (1994-01-01), Bannwarth et al.
patent: 5312527 (1994-05-01), Mikkelsen et al.
patent: 5328824 (1994-07-01), Ward et al.
patent: 5356786 (1994-10-01), Heller et al.
patent: 5391272 (1995-02-01), O'Daly et al.
patent: 5403451 (1995-04-01), Riviello et al.
patent: 5436161 (1995-07-01), Bergstrom et al.
patent: 5443701 (1995-08-01), Willner et al.
patent: 5449767 (1995-09-01), Ward et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5476928 (1995-12-01), Ward et al.
patent: 5552270 (1996-09-01), Khrapko et al.
patent: 5565552 (1996-10-01), Magda et al.
patent: 5571568 (1996-11-01), Ribi et al.
patent: 5573906 (1996-11-01), Bannwarth et al.
patent: 5591578 (1997-01-01), Meade et al.
patent: 5595908 (1997-01-01), Fawcett et al.
patent: 5601982 (1997-02-01), Sargent et al.
patent: 5620850 (1997-04-01), Bamdad et al.
patent: 5632957 (1997-05-01), Heller et al.
patent: 5700667 (1997-12-01), Marble et al.
patent: 5705348 (1998-01-01), Meade et al.
patent: 5741700 (1998-04-01), Ershov et al.
patent: 5756050 (1998-05-01), Ershov et al.
patent: 5770369 (1998-06-01), Meade et al.
patent: 5770721 (1998-06-01), Ershov et al.
patent: 5776672 (1998-07-01), Hashimoto et al.
patent: 5780234 (1998-07-01), Meade et al.
patent: 5824473 (1998-10-01), Meade et al.
patent: 5837859 (1998-11-01), Teoule et al.
patent: 5849486 (1998-12-01), Heller et al.
patent: 5851772 (1998-12-01), Mirzabekov et al.
patent: 5952172 (1999-09-01), Meade et al.
patent: 6066448 (2000-05-01), Wohlstadter et al.
patent: 6087100 (2000-07-01), Meade et al.
patent: 6096273 (2000-08-01), Kayyem et al.
patent: 6096825 (2000-08-01), Garnier
patent: 6177250 (2001-01-01), Meade et al.
patent: 6180352 (2001-01-01), Meade et al.
patent: 6200761 (2001-03-01), Meade et al.
patent: 6207369 (2001-03-01), Wohlstadter et al.
patent: 6238870 (2001-05-01), Meade et al.
patent: 6265155 (2001-07-01), Meade et al.
patent: 6291188 (2001-09-01), Meade et al.
patent: 2 090 904 (1993-09-01), None
patent: 0 063 879 (1982-11-01), None
patent: 0 234 938 (1987-02-01), None
patent: 0 229 943 (1987-07-01), None
patent: 0 599 337 (1994-01-01), None
patent: 0 589 867 (1996-04-01), None
patent: 0 515 615 (1996-09-01), None
patent: 238166 (1988-10-01), None
patent: 6-41183 (1994-02-01), None
patent: WO 86/05815 (1985-03-01), None
patent: WO 90/05303 (1990-05-01), None
patent: WO 90/05732 (1990-05-01), None
patent: WO 92/10757 (1992-06-01), None
patent: WO 93/10267 (1993-05-01), None
patent: WO 93/22676 (1993-11-01), None
patent: WO 94/22889 (1994-10-01), None
patent: WO 95/15971 (1995-06-01), None
patent: WO 96/40712 (1996-12-01), None
patent: WO 97/01646 (1997-01-01), None
patent: WO 97/27329 (1997-07-01), None
patent: WO 97/44651 (1997-11-01), None
patent: WO 98/27229 (1998-06-01), None
patent: WO 98/28444 (1998-07-01), None
patent: WO 98/35232 (1998-08-01), None
patent: WO 99/14596 (1999-03-01), None
patent: WO 99/37819 (1999-07-01), None
patent: WO 99/67425 (1999-12-01), None
Yguerabide et al., “Quantitative Fluorescence Method for Continuous Measurement of DNA hybridization Kinetics Using a Fluorescent Intercalator”, Anal. Bioch., vol. 228, p. 208-220 (1995).
Beattie et al., “Genosensor Technology,” Clinical Chemistry, 39(4):719-722 (1993).
Bamdad, C. “A DNA self-assembled monolayer for the specific attachment of unmodified double—or single stranded DNA,” Biophysical Journal, 75:1997-2003 (1988).
Aizawa, et al., “Integrated Molecular Systems for Biosensors,” Sensors and Acuators B Chemical, B 24-25:1-5 (1995).
Albers, et al., “Design of Novel Molecular Wires for Realizing Long-Distance Electron Transfer,” Biochemistry and Bioenergetics, 42:25-33 (1997).
Alleman, K.S., et al., “Electrochemical Rectification at a Monolayer-Modified Electrode,” J. Phys. Chem., 100:17050-17058 (1996).
Arkin, et al., “Evidence for Photoelectron Transfer Through DNA Intercalation,” J. Inorganic Biochem. Abstracts, 6th International Conference on Bioorganic Chemistry, 51(1) & (2):526 (1993).
Barisci, et al., “Conducting Polymer Sensors,” TRIP, 4(9):307-311 (1996).
Baum, R. M., “Views on Biological, Long-Range Electron Transfer Stir Debate,” C&EN, pp 20-23 (1993).
Bechtold, R., et al., “Ruthenium-Modified Horse Heart Cytochrome c: Effect of pH and Ligation on the Rate of Intramolecular Electron Transfer between Ruthenium(II) and Heme(III),”J. Phys. Chem., 90(16):3800-3804 (1986).
Beattie, et al., “Genosensor Technology,” Clinical Chemistry, 39(4):719-722 (1993).
Bidan, “Electroconducting conjugated polymers: new sensitive matrices to build up chemical or electrochemical sensors. A Review., ” Sensors and Actuators, B5:45-56 (1992).
Blonder, et al., “Three-dimensional Redox-Active layered Composites of Au—Au, Ag—Ag and Au-Ag Colloids,” Chem. Commun. 1393-1394 (1998).
Boguslavsky, L. et al., “Applications of redox polymers in biosensors,” Solid State Ionics, 60:189-197 (1993).
Bamdad, C. “A DNA self-assembled monolayer for the specific attachment of unmodified double—or single stranded DNA,” Biophysical Journal, 75:1997-2003 (1998).
Bowler, B. E., et al., “Long-Range Electron Transfer in Donor (Spacer) Acceptor Molecules and Proteins,”Progress in Inorganic Chemistry:Bioinorganic Chemistry, 38:259-322 (1990).
Brun, A. M., et al., “Photochemistry of Intercalated Quaternary Diazaaromatic Salts,”J. Am. Chem. Soc., 113:8153-8159 (1991).
Bumm, et al., “Are Single Molecular Wires Conducting?,” Science 271:1705-1707 (1996).
Cantor, C.R., et al., “Report on the Sequencing by Hybridization Workshop,” Genomics, 13:1378-1383 (1992).
Carr, et al., “Novel Electrochemical Sensors for Neutral Molecules,” Chem. Commun., 1649-1650 (1997).
Carter, et al., “Voltammetric Studies of the Interaction of Metal Chelates with DNA. 2. Tris-Chelated Complexes of Cobalt(III) and Iron(II) with 10-Phenanthroline and 2,2′-Bipyridine,” J. Am. Chem. Soc., 11:8901-8911 (1989).
Chang, I-JY, et al., “High-Driving-Force Electron Transfer in Metalloproteins: Intramolecular Oxidation of Ferrocylochrome c by Ru(2,2′-bpy)2(Im)(His-33)3+,”J. Am. Chem. Soc., 113:7056-7057 (1991).
Chidsey, et al., “Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold” Electroactive Self-Assembled Monolayers, J. Am. Chem. Soc., 112:4301-4306 (1990).
Chidsey, C.E.D., et al., “Free Energy and Tempe

Affiliated with

Also associated with

Rating

Metallic solid supports modified with nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metallic solid supports modified with nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metallic solid supports modified with nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3526198