Dimerizing agents, their production and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S291000, C540S456000, C540S455000

Reexamination Certificate

active

06984635

ABSTRACT:
Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.

REFERENCES:
patent: 4797368 (1989-01-01), Carter et al.
patent: 5139941 (1992-08-01), Muzyczka et al.
patent: 5173414 (1992-12-01), Lebkowski et al.
patent: 5252479 (1993-10-01), Srivastava
patent: 5310903 (1994-05-01), Goulet
patent: 5314471 (1994-05-01), Brauker et al.
patent: 5340903 (1994-08-01), Tetart et al.
patent: 5354678 (1994-10-01), Lebkowski et al.
patent: 5362718 (1994-11-01), Skotnicki
patent: 5373014 (1994-12-01), Failli et al.
patent: 5378836 (1995-01-01), Kao et al.
patent: 5387680 (1995-02-01), Nelson
patent: 5429821 (1995-07-01), Dorian et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5454935 (1995-10-01), Magaraggia
patent: 5525610 (1996-06-01), Caufield
patent: 5527907 (1996-06-01), Or
patent: 5583139 (1996-12-01), Or et al.
patent: 5658776 (1997-08-01), Flotte et al.
patent: WO 92/19595 (1992-11-01), None
patent: WO 93/13663 (1993-07-01), None
patent: WO 93/24641 (1993-12-01), None
patent: WO 94/02136 (1994-02-01), None
patent: WO 94/18207 (1994-08-01), None
patent: WO 94/18317 (1994-08-01), None
patent: WO 94/28938 (1994-12-01), None
patent: WO 95/02684 (1995-01-01), None
patent: WO 95/04521 (1995-02-01), None
patent: WO 95/16691 (1995-06-01), None
patent: WO 95/33052 (1995-12-01), None
patent: WO 96/06111 (1996-02-01), None
patent: WO 96/13597 (1996-05-01), None
patent: WO 96/20951 (1996-07-01), None
patent: WO 96/26285 (1996-08-01), None
patent: WO 96/39350 (1996-12-01), None
patent: WO 96/41865 (1996-12-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 97/08298 (1997-03-01), None
patent: WO 97/31899 (1997-09-01), None
patent: WO 98/02441 (1998-01-01), None
Aebischer, P. et al. “Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells”Experimental Neurology126(2):151-158 (1994).
Aitken, A. et al. “Idenitification of the NH2-Terminal Blocking Group of Calcineurin B as Myristic Acid” FEBSLetters150(2):314-318 (Dec. 1982).
Ao, Z. et al. “Microencapsulation Improves Canine Islet Survival In Vivo” et al.Transplantation Proceedings27(6):3349-3350 (Dec. 1995).
Behringer, R.R. et al. “Dwarf Mice Produced by Genetic Ablation of Growth Hormone-Expressing Cells”Genes&Development2:453-461 (1988).
Belshaw et al. “Controlling Protein Association and Subcellular Localization with a Synthetic Ligand That Induces Heterodimerizationof Proteins”Proc. Natl. Acad. Sci. U.S.A.93:4604-4607 (May 1996).
Borelli, E. et al. “Targeting of an Inducible Toxic Phenotype in Animal Cells”Proc. Natl. Acad. Sci. U.S.A.85:7572-7576 (Oct. 1988).
Breitman, M.L. et al. “Genetic Ablation in Transgenic Mice with an Attenuated Diphtheria Toxin A Gene”Molecular and Cellular Biology10:474-476 (Feb. 1990).
Breitman, M.L. et al. “Genetic Ablation: Targeted Expression of a Toxin Gene Causes Microphtalmia in Transgenic Mice”Science238:1563-1565 (Dec. 1987).
Brown, E.J. et al. “A Mammalian Protein Targeted by G1-Arresting Rapamycin-Receptor Complex”Nature369:756-758 (Jun. 1994).
Caldwell, R.C. and Joyce, G.F. “Randomization of Genes by PCR Mutagenesis”PCR Methods and Applications2:28-33 (1992).
Carr, S.A. et al “n-Tetradecanoyl is the NH2-Terminal Blocking Group of the Catalytic Subunit of Cyclic AMP-Dependent Protein Kinase from Bovine Cardiac Muscle”Proc. Natl. Acad. Sci. U.S.A.79:6128-6131 (Oct. 1982.
Carter et al. “Adeno-Associated Virus Vectors”Current Opin. In Biotech.3:533-539 (1992).
Chaffin, K.E. et al. “Dissection of Thymocyte Signaling Pathways by In Vivo Expression of Pertussis Toxin ADP-Ribosyltransferase”The EMBO Journal9(12):3821-3829 (1990).
Chang, P.L. et al. “Delivery of Recominbant Gene Products with Microencapsulated Cells In Vivo”Human Gene Therapy4:433-440 (1993).
Chen, J. “Identification of an 11-kDa FKBP12-rapamycin-binding Domain Within the 289-kDa FKBP12-rapamycin-associated Protein and Characterization of a Critical Serine Residue”Proc. Natl. Acad. Sci. U.S.A.92:4947-4951 (May 1995).
Chiu, M.I. et al. “RAPT1, a Mammalian Homolog of Yeast Tor, Interacts with the FKBP12/Rapamycin Complex”Proc. Natl. Acad. Sci. U.S.A.91:12574-12578 (Dec. 1994).
Clackson, T. and Wells, J.A. “In Vitro Selection from Protein and Peptide Libraries”TIBTECH12:173-184 (May 1994).
Crameri, A. et al. “Construction and Evolution of Antibody-Phage Libraries by DNA Shuffling”Nature Medicine2(1):100-103 (Jan. 1996).
Cunningham, B.C. and Wells, J.A. “High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis”Science244:1081-1085 (Jun. 1989).
Dennis, M.S. and Lazarus, R.A. “Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa”Journal of Biological Chemistry269(35)22129-22136 (1994).
Dubensky, T.W. et al. “Direct Transfection of Viral and Plasmid DNA into the Liver of Spleen of Mice”Proc. Natl. Acad. Sci. U.S.A.81:7529-7533 (Dec. 1984).
Emerich, D.F. et al. “Intrastriatal Implants of Polymer-Encapsulated PC12 Cells” Effects on Motor Function in Aged RatsProg. Neuro-Psychopharmacol.&Biol. Psychiat.18:935-946 (1994).
Emrich, D.F. et al. “Polymer-Encapsulated PC12 Cells Promote Recovery of Motor Functionin Aged Rats”Experimental Neurology122:37-47 (1993).
Ferry, N. et al. “Retroviral-Mediated Gene Transfer into Hepatocytes In Vivo”Proc. Natl. Acad. Sci. U.S.A.88:8377-8381 (Oct. 1991).
Fields, S. and Song, O-k “A Novel Genetic System to Detect Protein-Protein Interactions”Nature340:245-246 (Jul. 1989).
Fisher, K.J. et al. “Recombinant Adenovirus Deleted of All Viral Genes for Gene Therapy of Cystic Fibrosis”Virology217:11-22 (1996).
Flotte et al. “Expression of the Cystic Fibrosis Transmembrane Conductance Regulator from a Novel Adeno-Associated Virus Promoter”The Journal of Biological Chemistry268(5):3781-3790 (1993).
Goldman, M.J. et al. “Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study”Human Gene Therapy6:839-851 (Jul. 1995).
Hatzogluo, M. et al. “Hepatic Gene Transfer in Animals Using Retroviruses Containing the Promoter From the Gene for Phosphoenolpyruvate Carboxykinase”J. Biol. Chem.265(28):17285-17293 (1990).
Henderson, L.E. et al. “Myristyl Amino-Terminal Acylation of Murine Retrovirus proteins: An Unusual Post-Translational Protein Modification”Proc. Natl. Acad. Sci. U.S.A.80:339-343 (Jan. 1983).
Heyman, R.A. et al. “Thymidine Kinase Obliteration: Creation of Transgenic Mice with Controlled Immune Deficiency”Proc. Natl. Acad. Sci. U.S.A.86:2698-2702 (Apr. 1989).
Hiebert, S.W. et al. “E1A-Dependent Trans-Activation of the Human MYC Promoter is Mediated by the E2F Factor”Proc. Natl. Acad. Sci. U.S.A.86:3594-3598 (May 1989).
Ho, S.N. et al. “Dimeric Ligands Define a Role for Transcriptional Activation Domains in Reinitiation”Nature382:822-826 (Aug. 1996).
Holsinger, L.J. et al. “Signal transduction in T Lymphocytes Using a Conditional Allele of Sos”Proc. Natl. Acad. Sci. U.S.A.92:9810-9814 (Oct. 1995).
Hu, J.C. “Repressor Fusions as a Tool to Study Protein-Protein Interactions”Structure3:431-433 (May 1995).
Hu, J.C. et al. “Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions”Science250: 1400-1403 (Dec. 1990).
Joyner, A.L. et al. “Production of a Mutation in Mouse EN-2 Gene by Homologous Recombination in Embryonic Stem Cells”Nature338:153-156 (Mar. 1989).
Kaneda, Y et al. “Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver”Science243:375-3

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