Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-09
2006-05-09
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07041453
ABSTRACT:
The present invention relates to molecular constructs and methods of their use in detecting biochemical reactions. In particular, the invention relates to a molecular construct having a capture portion and a substrate portion, where the capture portion isolates the construct from a sample medium, and the substrate portion enables the construct to be acted upon and undergo a physical change which can be detected and measured. These molecular constructs may be used in diagnostic assays, genetic screening for potential risks of certain diseases in individuals, and drug discovery and toxicogenomics, using high throughput screening of compounds.
REFERENCES:
patent: 6063569 (2000-05-01), Gildea et al.
patent: 6316186 (2001-11-01), Ekins
patent: 1394270 (2004-03-01), None
patent: WO 96/02558 (1996-02-01), None
patent: WO 96/30392 (1996-10-01), None
patent: WO 96/41011 (1996-12-01), None
patent: WO 98/20153 (1998-05-01), None
patent: WO 9838334 (1998-10-01), None
patent: WO 98/53093 (1998-11-01), None
patent: WO 99/41273 (1999-08-01), None
patent: WO 99/51773 (1999-10-01), None
patent: WO 02/14864 (2002-02-01), None
patent: WO 03/058196 (2003-07-01), None
Koch et al., “PNA-Peptide Chimerae,” Tetrahedron Letters 36 : 6933-6936 (1995).
S. Basu, et al. “Synthesis and Characterization of a Peptide Nucleic Acid Comjugated to a D-Peptide Analog of Insulin-like Growth Factor 1 for Increased Cellular Uptake”. Bioconjugate Chem, 1997: 481-488. vol. 8, No. 4.
L. Good, et al. “Bactericidal antisense effects of peptide-DNA conjugates.” Nature Biotechnology, 2001: 360-364. vol. 19.
X. Zhang, et al. “Strand invasion by mixed base PNAs and a PNA-peptide chimera.” Nucleic Acids Research, 2000: 3332-3338. vol. 28, No. 17.
H. Hirata, et al. “Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis.” J. Exp. Med., 1998: 587-600. vol. 187, No. 4.
Dai-Wu Seol, et al. “Signaling Events Triggered by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL): Caspase-8 Is Required for TRAIL-induced Apoptosis.” Cancer Research, 2001: 1138-1143. vol. 61.
T. Kurita-Ochiai, et al. “Butyric Acid-Induced T-Cell Apoptosis Is Mediated by Caspase-8 and -9 Activation in a Fas-Independent Manner.” Clinical and Diagnostic Laboratory Immunology, 2001: 325-332. vol. 8, No. 2.
Applied Biosystems Product Information. “PNA Probe: Product Insert.”.
Pierce Product Information. “Tyrosine Kinase Assay Kits, ELISA Based.”.
Active Motif Product Information. “Total mVADER: mRNA Isolation from Total RNA.” www.activemotif.com.
Applied Biosystems Product Information. “PCR Licensing, Patents & Trademark.” http://www.appliedbiosystems.com/legal/pcrlicfaqs.cfm.
Applied Biosystems Service and Support. “Guidelines for Sequence Design of PNA Oligomers.” http://www.appliedbiosystems.com/support/seqguide.cfm.
Boston Probes, Inc. Company Information. “Company Overvie.” http://www.bostonprobes.com/content—pages/business—files/bus—companyoverview.html.
Boston Probes, Inc. Company Information. http://www,bostonprobes.com/pages/business/bus-lic.html.
Boston Probes, Inc. Product Information. “Ready-to-use PNA Probes and Kits.” http://www.bostonprobes.com/pages/products—files/products—PNA.html.
M. Pooga, et al. “PNA-Peptide Conjugates.” Nat. Biotechnol, 1998: 857-861.
“Breakthrough Application of PNA Technology in Genetic Analysis.” Doctor's Guide Publishing Limited, 1995. http://www.pslgroup.com/dg/ebea.htm.
PNA Diagnostics A/S Company Information.
“Peptide Nucleic Acid (PNA)”. http://www.highveld.com/pna.html.
P.E. Nielson et al. “Peptide Nucleic Acids: Protocols and Applications.” 1999. http://www.horizonpress.com/hsp/abs/abspna.html.
Casnellie Je, et al. “Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.” Proc Natl Acad Sci USA, 1982: 282-286. vol. 79, No. 2.
Pantheco Company Information. “Intellectual Property Rights.” http://www.pantheco.com/frrame.cfm?sprog=2&grp=1&menu=6.
NCBI Blast results. http://www.ncbi.nlm.nih.gov/blast/Blast.cgi.
NCBI Sequence Viewer.
Coriell Cell Repositories Product Information. “DNA Sample Characteristics.” http://locus.umdnj.edu
igms—cgi/display.cgi?NA06826.
Niemeyer et al., Oligonucleotide-directed self-assembly of proteins: semisynthetic DNA—streptavidin hybrid molecules as connectors for the generation of macroscopic arrays and the construction of supramolecular bioconjugates, Nucleic Acids Research, vol. 22: 5530-5539 (1994).
Niemeyer et al., DNA-Directed Immobilization: Efficient, Reversible, and Site-Selective Surface Binding of Proteins by means of Covalent Can Stretavidin conjugates, Analytical Biochemistry 268, 54-63 (1999).
European Search Report, Dec. 16, 2003.
Partial European Search Report, Mar. 19, 2004.
No affiliations
LandOfFree
Molecular constructs and methods of use for detection of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Molecular constructs and methods of use for detection of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecular constructs and methods of use for detection of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3524987