Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2006-07-18
2006-07-18
Kemmerer, Elizabeth (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S254110, C435S325000, C536S023100, C536S023500
Reexamination Certificate
active
07078221
ABSTRACT:
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4795804 (1989-01-01), Urist
patent: 4804744 (1989-02-01), Sen
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4877864 (1989-10-01), Wang et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5154931 (1992-10-01), Kruger et al.
patent: 5166058 (1992-11-01), Wang et al.
patent: 5187076 (1993-02-01), Wozney et al.
patent: 5250302 (1993-10-01), Oppermann et al.
patent: 5366875 (1994-11-01), Wozney et al.
patent: 5585237 (1996-12-01), Oppermann et al.
patent: 5614385 (1997-03-01), Oppermann et al.
patent: 5652118 (1997-07-01), Ozkaynak et al.
patent: 5670336 (1997-09-01), Oppermann et al.
patent: 5712119 (1998-01-01), Oppermann et al.
patent: 5863758 (1999-01-01), Oppermann et al.
patent: 6071695 (2000-06-01), Ozkaynak et al.
patent: 6261835 (2001-07-01), Oppermann et al.
patent: 0128041 (1984-12-01), None
patent: 0148155 (1985-07-01), None
patent: 0169016 (1986-01-01), None
patent: 0182483 (1986-05-01), None
patent: 0212474 (1987-03-01), None
patent: 85/05274 (1985-12-01), None
patent: 86/00526 (1986-01-01), None
patent: 88/00205 (1988-01-01), None
patent: 89/09605 (1989-10-01), None
patent: 89/10409 (1989-11-01), None
patent: 90/03733 (1990-04-01), None
patent: 90/11366 (1990-10-01), None
patent: 91/02744 (1991-03-01), None
patent: 93/00049 (1993-01-01), None
Canalis et al., “Stimulation of DNA and Collagen Synthesis by Antologous Growth Factor in Cultured Fetal Rat Calvaria,”Science210:1021-1023 (1980).
Centrella, “Transforming and Nontransforming Growth Factors are Present in Medium Conditioned by Fetal Rat Calvariae,”Proc. Natl. Acad. Sci. USA82:7335-7339 (1985).
Colowick et al.,Methods in Enzymology146:294-312 (1987).
Farley et al., “Human Skeletal Growth Factor: Characterization of Mitogenic Effect on Bone Cells In Vitro,”Biochem. 21:3508-3513 (1982).
Glowacki et al., “Application of the Biological Principle of Induced Osteogenesis for Craniofacial Defects,”Lancet1:959-963 (1981).
Klausner, “Collagen Corp. Isolates Cartilage Inducers,”Biotechnology3:567-568 (1985).
LeGendre et al., “Direct Protein Microsequencing from Immobilon-P Transfer Membrane,”Biotechniques6:154-159 (1988).
Lyons et al., “Vgr-1, A Mammalian Gene Related to Zenopus Vg-1, Is A Member of the Transforming Growth Factor B Gene Superfamily,”Proc. Natl. Acad. Sci. USA86:4554-4558 (1989).
Maugh, “Human Skeletal Growth Factor Isolated,”Science217:819 (1982).
Olson et al., “Deglycosylation of Chondroitin Sulfate Proteoglycan by Hydrogen Fluoride in Pyridine,”Analyt. Biochem.146:232-257 (1985).
Padgett et al., “A Transcript From A Drosophila Pattern Gene Predicts A Protein Homologous To The Transforming Growth Factor-B Family,”Nature325:81-84 (1987).
Reddi, “Cell Biology and Biochemistry of Endochondral Bone Development,”Collage Rel. Res.1:209-226 (1981).
Reddi, “Implant-Stimulated Interface Reactions During Collagens Bone Matrix-Induced Bone Formation,”Journal of Biomedical Materials Research19:233-239 (1985).
Rosen et al., “Purification and Molecular Cloning of a Novel Group of BMPs”,Connect. Tissue Res.20:313-319 (1989).
Rudinger, “Characteristics of the Amino Acids as Components of a Peptide Hormone Sequence,”Peptide Hormones(Parsons, et al. ed.), University Park Press, Baltimore, 1-7 (1976).
Sampath et al., “Dissociative Extraction and Reconstitution of Extracellular Matrix Components Involved in Local Bone Differentiation,”Proc. Natl. Acad. Sci. USA78:7599-7603 (1981).
Sampath et al., “Drosophila Transforming Growth Factor β Superfamily Proteins,”Proc. Natl. Acad. Sci. USA90:6004-6008 (Jul. 1993).
Sampath et al., “Isolation of Osteogenin, An Extracellular Matrix-Associated, Bone-Inductive Protein, by Heparin Affinity Chromatography,”Proc. Natl. Acad. Sci. USA84:7109-7113 (1987).
Sampath et al., “Role of Extracellular Matrix Components in Cartilage and Bone Induction,”Extracellular Matrix: Structure and Function(A.H. Reddi Ec.)Allen R. Liss, Publ., NY412-428 (1985).
Sampath et al., “Homology of Bone-Inductive Proteins from Human, Monkey, Bovine, and Extracellular Matrix,”Proc. Natl. Acad. Sci. USA, 80:6591-6595 (1983).
Seyedin et al, “In Vitro Induction of Cartilage-Specific Macromolecules by a Bone Extract,”Proc. Natl. Acad. Sci. USA82:2267-2271 (1985).
Seyedin et al., “Purification and Characterization of Two Cartilage-Inducing Factors from Bovine Demineralized Bone,”J. Cell Biol.97:1950-1953 (1983).
Simpson, “Growth Factors Which Affect Bone,”Trends Biochem. Sci.9:527-530 (1984).
Urist et al., “B-tricalcium Phosphate Delivery System for Bone Morphogenetic Protein,”Clin. Orth. Rel. Res.187:277-280 (1984).
Urist et al., “Human Bone Morphogenic Protein (hBMP),”Proc. Soc. Exp. Bio. Med.173:194-199 (1983).
Urist et al., “Purification of Bovine Bone Morphogenetic Protein by Hydroxyapatite Chromatography,”Proc. Natl. Acad. Sci. USA81:371-375 (1984).
Wang et al., “Purification and Characterization of Cartilage and Bone Inducing Factors,”Calcified Tissue Int.(Suppl) Ab No. 146, pp. A37 (1988).
Wang et al., “Purification and Characterization of Other Distinct Bone-Inducing Factors,”Proc. Natl. Acad. Sci. USA85:9484-9488 (1988).
Wang et al., “Recombinant Human Bone Morphogenetic Protein Induces Bone Formation,”PNAS87:2220-2224 (1990).
Weeks et al., “A Maternal mRNA Localized to the Vegetal Hemisphere in Xenpus Eggs Codes For A Growth Factor Related to TGF-B,”Cell51:861-867 (1987).
Wozney et al., “Identification Through Molecular Cloning of Factors Involved in Vivo Cartilage Formation,”Calcified Tissue Int.(Suppl.) Ab No. 147, A37 (1988).
Wozney et al., “Novel Regulators of Bone Formation: Molecular Clones & Activities,”Science242:1528-1534 (1988).
Kuberasampath Thangavel
Oppermann Hermann
Ozkaynak Engin
Rueger David C.
Kemmerer Elizabeth
Kirkpatrick & Lockhart Nicholson & Graham LLP
Stryker Biotech
LandOfFree
Nucleic acid molecules encoding osteogenic proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules encoding osteogenic proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules encoding osteogenic proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3524395