Crosslinked amide derivatives of hyaluronic acid and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S053000, C536S055100, C536S124000

Reexamination Certificate

active

06903199

ABSTRACT:
The present invention relates to water-insoluble, crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof, where the amide derivatives of hyaluronic acid are characterized by crosslinking, of polymer or oligomer having two or more amine groups, with hyaluronic acid or its hyaluronate salts through amidation reaction. The water-insoluble, crosslinked amide derivatives of hyaluronic acid according to the present invention may be diversely used for prevention of adhesion after surgical operation, correction of facial wrinkles, dermal augmentation, tissue engineering, osteoarthritic viscosupplement etc.

REFERENCES:
patent: 4582865 (1986-04-01), Balazs et al.
patent: 4713448 (1987-12-01), Balazs et al.
patent: 5017229 (1991-05-01), Burns et al.
patent: 5760200 (1998-06-01), Miller et al.
patent: 5874417 (1999-02-01), Prestwich et al.
patent: WO 86/00912 (1986-02-01), None

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