Nucleic acid ligand binding site identification

Details Nucleic acid ligand binding site identification Nucleic acid ligand binding site identification

2005-08-23

2005-08-23

Forman, BJ (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C436S501000, C536S023100, C536S024300, C536S024330, C536S025400, C530S300000, C530S350000

Reexamination Certificate

active

06933116

ABSTRACT:
This invention comprises nucleic acid ligand for use as a diagnostic reagent for detecting the presence or absence of a target molecule in a sample, and a diagnostic reagent to measure the amount of a target molecule in a sample. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified by further partitioning.

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