Human and mouse very low density lipoprotein receptors and metho

Details Human and mouse very low density lipoprotein receptors and metho Human and mouse very low density lipoprotein receptors and metho

1995-05-26

1998-08-25

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 243, 536 2433, 435 912, C12Q 168, C12P 1934, C07H 2104, C07H 2102

Patent

active

057982090

ABSTRACT:
Methods of treating diseases or conditions, characterized by elevated serum lipoprotein levels, by providing elevated levels of a VLDL receptor in an animal, e.g., a human are set forth. Such receptors aid in removal of circulating VLDL and related lipoproteins, and thus decrease the risk of developing coronary diseases or conditions or decrease the severity of such diseases or conditions. Clones of human and mouse VLDL receptor which can be used in the invention are also provided. Vectors for the expression of VLDL receptors, stably transfected and transformed cells and transgenic animals are also provided.

REFERENCES:
patent: 4870009 (1989-09-01), Evans et al.
patent: 4873316 (1989-10-01), Meade et al.
Takahashi et al. PNAS 89: 9252-9256, 1992.
Nora and Fraser, in Medical Genetics: Principles and Practices, Lea and Febiger, pp. 120-129, 1989.
Sakai et al. Genebank Sequence Listing, 1993.
Beisiegel et al., "Lipoprotein Lipase Enhances the Binding of Chylomicrons to Low Density Lipoprotein Receptor-Related Protein," 88 Proc. Natl. Acad. Sci. USA 8342, 1991.
Blankenhorn et al., "Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts," 257 JAMA 3233, 1987.
Brown et al., "Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with Hight Levels on Apolipoprotein B," 323 N. Engl. J. Med. 1289, 1990.
Burns et al., "Vesicular Stomatitis Virus G Glycoprotein Pseudotyped Retroviral Vectors: Concentration to Very High titer and Efficient Gene Transfer into Mammalian and Nonmammalian Cells," 90 Proc. Natl. Acad. Sci. USA 8033, 1993.
Chan et al., "Molecular Genetics of the Plasma Apolipoproteins," In: Molecular Biology of the Cardiovascular System, Chien ed., Lea & Febiger, Philadelphia, London, pp. 183-219, 1990 vol. # not applicable.
Chappell et al., "The Low Density Lipoprotein Receptor-Related Protein/.alpha..sub.2 -Macroglobulin Receptor Binds and Mediates Catabolism of Bovine Milk Lipoprotein Lipase," 267 J. Biol. Chem. 25764, 1992.
Chen et al., "NPXY, a Sequence Often Found in Cytoplasmic Tails, is Required for Coated Pit-Mediated Internalization of the Low Density Lipoprotein Receptor," 265 J. Biol. Chem. 3116, 1990.
Chowdhury et al, "Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits," 254 Science 1802, 1991.
Cristiano et al, "Hepatic Gene Therapy: Adenovirus Enhancement of Receptor-Mediated Gene Delivery and Expression in Primary Hepatocytes," 90 Proc. Natl. Acad. Sci. USA 2122, 1993.
Curiel et al., "Adenovirus Enhancement of Transferrin-Polylysine-Mediated Gene Delivery," 88 Proc. Natl. Acad. Sci. USA 8850, 1991.
Davis et al., "Acid-Dependent Ligand Dissociation and Recycling of LDL Receptor Mediated by Growth Factor Homology Region," 326 Nature 760, 1987.
Denmacker et al., "Increased Removal of .beta.-Very Low Density Lipoproteins after Ethinyl Estradiol is Associated with Increased mRNA Levels for Hepatic Lipase, Lipoprotein Lipase, and the Low Density Lipoprotein Receptor in Watanabe Heritable Hyperlipidemic Rabbits," 11(6) Arteriosclerosis and Thrombosis 1652, 1991.
Eisenberg et al., "Lipoprotein Lipase Enhances Binding of Lipoproteins to Hepran Sulfate on Cell Surfaces and Extracellular Matrix," 90 J. Clin. Invest. 2013, 1992.
Esser et al., "Mutational Analysis of the Ligand Binding Domain of the Low Density Lipoprotein Receptor," 263 J. Biol. Chem. 13282, 1988.
Goldstein et al., "Receptor-Mediated Endocytosis of Low-Density Lipoprotein in Cultured Cells," 98 Methods Enzymol. 241, 1983.
Chan, "Genes, Dyslipoproteinemia and Coronary Artery Disease,"In: Treatment of Severe Hypercholesterolemia in the Prevention of Coronary Heart Disease--Gotto et al. (eds), Proc 2nd Int Symp Munich 1989, Basel, Karger, pp. 1-11, 1990 vol. 2.
Graham and Prevec, "Manipulation of Adenovirus Vectors," 7 Methods in Molecular Biology 109-128, E.J. Murray, ed., Humana Press, NJ, 1991.
Grossman et al., "Transplantation of Genetically Modified Autologous Hepatocytes into Nonhuman Primates: Feasibility and Short-Term Toxicity," 3(5) Human Gene Therapy 501, 1992.
Kamps et al., "Complete Down-Regulation of Low-Density Lipoprotein Receptor Activity in Human Liver Parenchymal Cells by .beta.-very-low-density Lipoprotein," 287 FEBS 34, 1991.
Kane et al., "Normalization of Low-Density-Lipoprotein Levels in Heterozygous Familial Hypercholesterolemia with a Combined Drug Regimen," 304 N. Engl. J. Med. 251, 1981.
Kaneda et al., "The Improved Efficient Method for Introducing Macromolecules into Cells Using HVJ (Sendai Virus) Liposomes with Gangliosides," 173 Expt. Cell Res. 56, 1987.
Kaneda et al., "Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver," 243 Science 375, 1989.
Lee et al., "Nucleotide Sequence of the Rat Low Density Lipoprotein Receptor cDNA," 17(3) Nucleic Acids Research 1259, 1989.
Lindgren et al., "Human Genes Involved in Cholesterol Metabolism: Chromosomal Mapping of the Loci for the Low Density Lipoprotein Receptor and 3-hydroxy-3-methylglutarly-coenzyme A Reductase with cDNA Probes," 82 Proc. Natl. Acad. Sci. USA 8567, 1985.
van den Maagdenberg et al., "Transgenic Mice Carrying the Apolipoprotein E3-Leiden Gene Exhibit Hyperlipoproteinemia," 268(14) J. Biol. Chem. 10540, 1993.
Maniatis, Fritsch and Sambrook, Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1982 vol. #, pp. #' not applic.
Mehta et al., "The Low Density Lipoprotein Receptor in Xenopus laevis," 266(16) J. Biol. Chem. 10415, 1991.
Miller, "Retrovirus Packaging Cells," 1 Hum. Gene Ther. 5, 1990.
Morgan and Anderson, "Human Gene Therapy," 62 Annu. Rev. Biochem. 191, 1993.
Mulder et al., "Low Density Lipoprotein Receptor Internalizes Low Density and Very Low Density Lipoproteins that are Bound to Heparan Sulfate Proteoglycans via Lipoprotein Lipase, " 268 J. Biol. Chem. 9369, 1993.
Rumsey et al., "Lipoprotein Lipase-Mediated Uptake and Degradation of Low Density Lipoproteins by Fibroblasts and Macrophages," 90 J. Clin. Invest. 1504, 1992.
Russell et al., "Different Combinations of Cysteine-Rich Repeats Mediate Binding of Low Density Lipoprotein Receptor to Two Different Proteins," 264 J. Biol. Chem. 21682, 1989.
Takahashi et al., "Rabbit Very Low Density Lipoprotein Receptor: A Low Density Lipoprotein Receptor-Like Protein with Distinct Ligand Specificity," 89 Proc. Natl. Acad. Sci. USA 9252, 1992.
Williams "Gene Therapy for Ischemic Heart Disease: Current Prospects," 5(1) J. Myocardial Ischemia 13, 1993.
Williams et al., "Mechanisms by Which Lipoprotein Lipase Alters Cellular Metabolism of Lipoprotein(a), Low Density Lipoprotein, and Nascent Lipoproteins," 267 J. Biol. Chem. 13284, 1992.
Wislow et al., "Ex Vivo Gene Therapy of Familial Hypercholesterolemia," 3(2) Human Gene Therapy 179, 1992.
Wolff et al., "Direct Gene Transfer into Mouse Muscle In Vivo," 247 Science 1465, 1990.
Wu et al., "Receptor-Mediated Gene Delivery In Vivo. Partial Correction of Genetic Analbuminemia in Nagaes Rats," 266 J. Biol. Chem. 14338, 1991.
Wu and Wu, "Receptor-Mediated In Vitro Gene Transformation by a Soluble DNA Carrier System," 262 J. Biol. Chem. 4429, 1987.
Yamamoto et al., "The Human LDL Receptor: A Cysteine-Rich Protein with Multiple Alu Sequences in its mRNA," 39 Cell 27, 1984.
Yamamoto et al., "Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit," 232 Science 1230, 1986.
Yang et al., "Human Very Low Density Lipoprotein Structure: Interaction of the C Apolipoproteins with Apolipoprotein B-100," 34 J. Lipid Research 1311, 1993.
Yokode et al., "Diet-Induced Hypercholesterolemia in Mice: Prevention by Overexpression of LDL Receptors," 250 Science 1273, 1990.
Zhu et al., "Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice," 261 Science 209, 1993.
NCEP Adult Treatment Panel II Report, "Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adul

Affiliated with

Also associated with

Rating

Human and mouse very low density lipoprotein receptors and metho does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human and mouse very low density lipoprotein receptors and metho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human and mouse very low density lipoprotein receptors and metho will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-35205