Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-06-28
2005-06-28
Cook, Rebecca (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S343000, C514S250000, C514S319000
Reexamination Certificate
active
06911475
ABSTRACT:
The present invention concerns the use of nicotine or a derivative thereof for producing a drug for continuous or progressive administration of 0.2 mg to 5 mg per day per kilogram of body weight in man, said drug being administered simultaneously with L-DOPA in a dose at least 30% lower than the effective dose when L-DOPA is administered alone.
REFERENCES:
patent: 5232933 (1993-08-01), Lippiello et al.
patent: 5242935 (1993-09-01), Lippiello et al.
Medline AN 86017126, Lieberman et al, Pharmacological Reviews, 1985 Jun. 37(2) 217-27, abstract.
A.M. Janson, et al./Brain Research (1994) 655: 25-32.
Trends Neurosciences, Olanow, C.W., et al., (1996) 19: p. 102-109.
E. F. Domino et al; Nicotine Alone and in Combination with L-DOPA Methyl Ester . . . vol. 158 (1999) p. 414-421.
Pharmacology of Nicotine and its Therapeutic Use in Smoking, David J. K. Balfour, et al., (1996) 72: vol. 1: 51-81.
J. Doyon et al., M Medecine et Science (1999), 5:XIX-XXIII and English Translation of same p. 1-6.
Cesaro Pierre
Villafane Gabriel
Assistance Publique-Hopitaux de Paris
Cook Rebecca
Lerner David Littenberg Krumholz & Mentlik LLP
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