Process for producing N-tertiary butoxycarbonyl-maleinimide

Details Process for producing N-tertiary butoxycarbonyl-maleinimide Process for producing N-tertiary butoxycarbonyl-maleinimide

1991-12-20

1993-03-16

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20724

Patent

active

051946297

ABSTRACT:
To produce N-tertiary butoxycarbonyl-maleinimide, maleinimide is reacted in the presence of a heterocyclic nitrogen compound having at least one tertiary nitrogen atom (as a base) with a more or less equimolar quantity of di-tertiary butyl-dicarbonate in a suitable solvent at temperatures of up to about 80.degree. C.

REFERENCES:
patent: 4725680 (1988-02-01), Barcelo et al.
patent: 4775609 (1988-10-01), McFarland
patent: 4827124 (1989-06-01), Wu et al.
patent: 4912018 (1990-03-01), Osuch et al.
patent: 4968581 (1990-11-01), Wu et al.
Chemical Abstracts, vol. 83 (1975) No. 28548X "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides", Keller et al.
"A Mild Two-Step Method for the Hydrolysis/Methanolysis of Secondary Amides and Lactams" 48, J. Org. Chem. pp. 2424-2426 (1983), Flynn, et al.
Y96 Applied Chemistry, pp. 291-292 (1984), Grehn, et al. Angew. Chem.

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