Process for preparation of thiazolylalkoxy acrylates

Details Process for preparation of thiazolylalkoxy acrylates Process for preparation of thiazolylalkoxy acrylates

1991-11-18

1993-03-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548236, 5483411, 548248, 5483114, 5483111, 5483154, 5483157, 5483167, 5483171, 5483235, 5483251, 5483421, 560 55, 544133, 544137, 544139, 544238, 544369, 544370, 546275, 546276, 546280, C07D27720

Patent

active

051946220

ABSTRACT:
A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, --SO.sub.2 alk and alk is alkyl of 1 to 8 carbon atoms, optionally substituted aryl, aryloxy and arylthio of 6 to 18 carbon atoms and optionally substituted heteroaryl, heteroaryloxy and heterocyclic of 5 to 6 ring members, R.sub.3 is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, aryl of 6 to 18 carbon atoms and alkoxyalkoxyalkyl of 3 to 14 carbon atoms, X is selected from the group consisting of --O--, --S-- and --NR.sub.4 --, R.sub.4 is selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl of up to 8 carbon atoms, --SO.sub.2 alkyl, --SO.sub.2 alkenyl and --SO.sub.2 alkynyl of up to 8 carbon atoms and optionally substituted aryl and --SO.sub.2 aryl of 6 to 18 carbon atoms, the double bond between the heterocycle of 5 member ring and the aromatic nucleus is of E and/or Z geometry comprising reacting a halide of the formula ##STR2## wherein R.sub.3 is as defined above and Hal is hydrogen with a compound of the formula ##STR3## wherein X, R.sub.1 and R.sub.2 have the above definitions in the presence of a base to obtain the corresponding product of formula I in the form of a mixture of isomers and optionally separating the isomers and novel intermediates of formula II.

REFERENCES:
patent: 2946824 (1960-07-01), Chiddix
patent: 3524886 (1970-08-01), Fried
patent: 4927960 (1990-05-01), Maeda
patent: 4937372 (1990-06-01), Wenderoth et al.
patent: 5003101 (1990-06-01), Brand et al.
patent: 5041618 (1991-08-01), Brand et al.
Schuetz et al. Chem. Abstr. vol. 113 entry 152422h (1990).

Affiliated with

Also associated with

Rating

Process for preparation of thiazolylalkoxy acrylates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of thiazolylalkoxy acrylates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of thiazolylalkoxy acrylates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-351769