7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids

Details 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids

1993-07-21

1996-06-11

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540301, C07D49804, A61K 31535

Patent

active

055255990

ABSTRACT:
The invention provides compounds of the formula ##STR1## wherein X is CH.sub.2, S or O; R.sub.1 is a 3 position substituent such as hydrogen, hydroxy, halo, trifluoromethyl, C.sub.2 F.sub.5, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 substituted alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl, CH.sub.2 O(CO)R', CH.sub.2 O(CO)NH.sub.2, CO.sub.2 R', thio(C.sub.1 -C.sub.6)alkyl, thio(C.sub.1 C.sub.6)alkenyl, oxo(C.sub.1 -C.sub.6)alkyl, phosphine oxide, quaternary ammonium group, substituted or unsubstituted thiazolothio, or oxo(C.sub.1 -C.sub.6)alkenyl;

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patent: 5019571 (1991-05-01), Cook et al.
patent: 5077287 (1991-12-01), Ternansky
patent: 5084447 (1992-01-01), Ternansky
patent: 5128336 (1992-07-01), Cook et al.
patent: 5158946 (1992-10-01), Gasson et al.

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