Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino

Details Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino

1991-06-11

1993-03-16

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540454, 549267, 544127, 544148, 548429, A61K 31395, C07D24502

Patent

active

051946050

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.

REFERENCES:
patent: 4477440 (1984-10-01), Boger et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4665052 (1987-05-01), Boger et al.
patent: 4743584 (1988-05-01), Boger et al.
patent: 4782043 (1988-11-01), Boger et al.
patent: 4921855 (1990-05-01), Hemmi et al.
Sham et al., Renin Inhibitors. Design and Synthesis of a New Class of Conformationally Restricted Analogues of Angiotensinogen, J. Med. Chem., 31, 284-295 (1988).
Burger, Hypotensive Drugs, Medicinal Chemistry pp. 565-581, 600-601 (1960).
Haber, et al., Renin Inhibitors: A Search for Principles of Design, Journal of Cardiovascular Pharmacology 10 (suppl. 7) 857-858 (1987).
Plattner et al., Renin Hibitors, J. Med. Chem. 31, pp. 2277-2288 (1988).
Denkewalter et al., Progress in Drug Research, 10, pp. 510-512 (1966).
Bolis et al., Renin Inhibitors, J. Med. Chem., 30, pp. 1729-1737 (1987).
"Feslk et al., Structural Refinement of a Cyclic Peptide.", Biochemistry 26, pp. 1851-1859 (1987).
Deber et al., Renin Inhibition, Proceeding of the 9th AM. Peptides Syn. pp. 754-759 (1985).

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