Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-11-08
2005-11-08
Qazi, Sabiha (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C514S182000, C552S521000, C558S029000
Reexamination Certificate
active
06962909
ABSTRACT:
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
REFERENCES:
patent: 5192756 (1993-03-01), Zasloff et al.
patent: 5792635 (1998-08-01), Zasloff
Sills Jr. et al, Squalamine Inhibits Angiogenesis and Solid Tumor Growth in Vivo Perturbs Embyronic Vasculature, Jul. 1, 1998, Cancer Research, 58, 2784-2792.
Higgins et al, Squalamine Improves Retinal Neovascularization, May 2000, Investigative Ophthalmology & Visual Science, vol. 41, No. 6, pp. 1507-1512.
PRNEWSWIRE, Genaera Reports Squalamine Continues to Improve Vision at Four Months Timepoint in Age-Related Macular Degeneration, Oct. 7, 2003, http://www.eyesightnews.com/topic/28.html.
Jones Steven
Kinney William
Shinnar Ann
Zasloff Michael
Genaera Corporation
Morgan & Lewis & Bockius, LLP
Qazi Sabiha
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