Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-03-03
1993-03-16
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303879, 5303881, 530808, 530864, 435 7021, 424 858, C07K 1528
Patent
active
051945924
ABSTRACT:
Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different aminoacid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, and methods of producing the hG-CSF polypeptide derivatives using the microorganisms are described.
REFERENCES:
patent: 4703008 (1987-12-01), Lin
patent: 4810643 (1989-01-01), Souza
Souza et al, Blood 66 1985 102(a).
Sevier et al, Clin Chem 27/u, 1981, pp. 1797-1806.
Kipps et al., Handbook of Experimental Immunol, ed Weir et al, 1986, pp. 108.1-108.9
Nature, vol. 319, Jan. 30, 1986, by S. Nagata, "Molecular Cloning and Expression of cDNA for Human Granulocyte Colony Stimulating Factor" pp. 415-418.
Science, vol. 232, No. 4746 Apr. 4, 1986, by Souza et al, "Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells", pp. 61-65.
Draper Garnette D.
Kyowa Hakko Kogyo Co. Ltd.
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