Quinazolinone compounds useful in therapy

Details Quinazolinone compounds useful in therapy Quinazolinone compounds useful in therapy

2005-08-30

2005-08-30

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S266210, C544S284000, C544S287000

Reexamination Certificate

active

06936619

ABSTRACT:
Compounds of formula (I):or pharmaceutically acceptable salts or solvates thereof, whereinR1represents C1-4alkyl;R2represents halo, C1-4alkyl, C3-6cycloalkyl, C3-6cycloalkyloxy, —SO2(C1-4alkyl), optionally substituted C1-4alkyloxy, Het or —OHet;R3represents a bicyclic group of the formula wherein X and Y are selected from C and N, provided that at least one is C;Ring A together with X and Y represents a 5- or 6-membered aromatic ring containing 0, 1, 2 or 3 nitrogen atoms in the ring;n is), 1 or 2L represents a direct link, C1-4alkylene or C1-4alkoxyalkylene;R4represents H, —NR5R6, C3-6cycloalkyl, —OR7, Het1or Het4;R5and R6are independently selected from H, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkylene, —SO2(C1-4alkyl) and optionally substituted C1-4alkylR7is selected from H, C1-4alkyl, C1-4alkoxyalkyl, C3-6cycloalkyl, Het2and C1-4alkyl-Het3;R8is H or C1-4alkyl;Het, Het1, Het2and Het3independently represent an optionally substituted 4 to 7 membered saturated heterocyclic group which may be mono- or bi-cyclic and which contains one or more heteroatoms selected from N, O or S;Het4represents an optionally substituted 5 or 6 membered unsaturated heterocyclic group containing one or more heteroatoms selected from N, O or S;R9is H or C1-4alkyl;R10and R11are independently selected from H and C1-4alkyl;are useful in the treatment of hypertension, myocardial infarction, male erectile dysfunction (MED), hyperlipidaemia, cardiac arrhythmia, glaucoma and benign prostatic hyperplasia (BPH). They also find utility in the treatment of female sexual arousal dysfunction (FSAD).

REFERENCES:
patent: 4085213 (1978-04-01), Bindra
patent: WO 9723462 (1997-07-01), None
patent: WO 9830560 (1998-07-01), None
patent: WO 02053558 (2002-07-01), None

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