Self-extinguishing recombinases, nucleic acids encoding them...

Details Self-extinguishing recombinases, nucleic acids encoding them... Self-extinguishing recombinases, nucleic acids encoding them...

2005-02-08

2005-02-08

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S320100, C514S04400A, C800S008000

Reexamination Certificate

active

06852530

ABSTRACT:
Nucleic acid molecules comprising at least a first signal site and a recombinase gene operably linked to an expression control sequence, such that upon entry into a cell, there is a first signal site and a second signal site positioned to mediate excision of a sufficient portion of either the recombinase gene or the expression control sequence to extinguish recombinase activity when the first and second signal sites are contacted with a recombinase, cells, transgenics and uses of the foregoing.

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