Hemoglobin alpha chain peptide fragments useful for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S385000

Reexamination Certificate

active

06858583

ABSTRACT:
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.

REFERENCES:
patent: 4350683 (1982-09-01), Galfre et al.
patent: 4683194 (1987-07-01), Saiki et al.
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5239061 (1993-08-01), Fronticelli et al.
patent: 5334706 (1994-08-01), Przybelski
patent: 5449759 (1995-09-01), Hoffman et al.
patent: 5631219 (1997-05-01), Rosenthal et al.
patent: 5786334 (1998-07-01), Petrov et al.
patent: 5861483 (1999-01-01), Wolpe
patent: 5939391 (1999-08-01), Tsyrlova et al.
patent: 6022848 (2000-02-01), Kozlov et al.
patent: 6090782 (2000-07-01), Tsyrlova et al.
patent: 1614655 (1988-05-01), None
patent: 1561261 (1998-04-01), None
patent: WO 9013645 (1990-11-01), None
patent: WO 9104274 (1991-04-01), None
patent: WO 9211283 (1992-07-01), None
patent: WO 92 20369 (1992-11-01), None
patent: WO 9309143 (1993-05-01), None
patent: WO 9405785 (1994-03-01), None
patent: WO 9524213 (1995-09-01), None
Becker et al. “The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice” Blood 26(3): 296-308 (1965).
Broxmeyer et al. “Involvement of the MU Opioid Receptor in Myeloid Progenitor Cell Proliferation: Evidence from MU Opioid Receptor Gene Knockout Mice” Blood 88:338a, Abstract 1339 (1996).
Broxmeyer et al. “Myelopoietic Enhancing Effects of Murine Macrophage Inflammatory Proteins 1 and 2 on Colony Formation In Vitro by Murine and Human Bone Marrow Granulocyte/Macrophage Progenitor Cells” J Exp Med 170:1583-1594 (1989).
Byron “Effect of Steroids on the Cycling of Haemopoietic Stem Cells” Nature 228:1204 (1970).
Davatelis et al. “Cloning and Characterization of cDNA for Murine Macrophage Inflammatory Protein (MIP), a Novel Monokine with Inflammatory and Chemokinetic Properties” J Exp Med 157:1939-1944 (1988).
Davatelis et al. “Macrophage Inflammatory Protein-1: A Prostaglandin-Independent Endogenous Pyrogen” Science 243:1066-1068 (1989).
Dexter et al. “Loss of Immunoreactivity in Long-Term Bone Marrow Culture” Nature 275:135-136 (1978).
Dunlop et al. “Demonstration of Stem Cell Inhibition and Myeloprotective Effects of SCI/rhMIP1α In Vivo” Blood 79(9):2221-2225 (1992).
Eaves et al. “Clinical Significance of Long-Term Cultures of Myeloid Blood Cells” CRC Critical Reviews in Oncology/Hematology 7(2):125-138 (1987).
Eaves et al. “The Therapeutic Potential of Long-Term Cultures of Myeloid CML Marrow Cultures” The Biology of Hematopoiesis (Daniak, ed.,), Alan R. Liss, NY.
Eaves et al. “Maintenance and Proliferation Control of Primitive Hemopoietic Progenitors in Long-Term Cultures of Human Marrow Cells” Blood Cells 14:355-368 (1988).
Eaves et al. “Mechanisms That Regulate the Cell Cycle Status of Very Primitive Hematopoietic Cells in Long-Term Human Marrow Cultures. II. Analysis of Positive and Negative Regulators Produced by Stromal Cells Within the Adherent Layer” Blood 78(1):110-117 (1991).
Enoki et al. “Preparation of Native α and β Subunits from Canine Hemoglobin” Biochim Biophys Acta 744:71-75 (1983).
Goldberg et al. “Regulatory Effects of Opioid Peptides on Bone Marrow Hematopoiesis in Stress” (abstract only) Biull Eksp Biol Med 108(8):216-219 (1989).
Goldberg et al. “The Modulating Influence of Enkephalins on the Bone Marrow Haemopoiesis in Stress” Folia Biologica (Praha) 36(6):319-331 (1990).
Golovanova et al. “Influence of the Factor of Stem Cell Inhibition on the Formation of Hemopoietic Colonies” Ontogenez 13(3):243-250 (1982).
Graham et al. “Identification and Characterization of an Inhibitor of Haemopoietic Stem Cell Proliferation” Nature 344:442-444 (1990).
Harrison et al. “Most Primitive Hematopoietic Stem Cells Are Stimulated to Cycle Rapidly After Treatment With 5-Fluorouracil” Blood 78(5):1237-1240 (1991).
Hunkapiller et al. “Isolation of Microgram Quantities of Proteins from Polyacrylamide Gels for Amino Acid Sequence Analysis” Meth Enzymol 91:227-236 (1983).
Hwang et al. “Identification of Residues Involved in the Binding of Hemoglobin α Chains to Haptoglobin” J Biol Chem 254(7):2265-2270 (1979).
Ignat'Eva et al. “Study of the Mechanism of Action of the Stem Cell Inhibition Factor on the Formation of Exogenous Hemopoietic Colonies in the Spleen on Mice” (abstract only) Biull Eksp Biol Med 98(9):326-329 (1984).
James et al. “The Isolation of the γ Subunit of Fetal Hemoglobin (HbF) and Its Use in a Radioimmunoassay for HbF” J Immunol Meth 32:251-260 (1980).
Karelin et al. “Proteolytic Degradation of Hemoglobin in Erythrocytes Leads to Biologically Active Peptides” Peptides 16(4):693-697 (1995).
Kozlov et al. “The Effect of Haemopoietic Stem Cell Proliferation on the Humoral Immune Response in Mice” Cell Tissue Kinet 20:485-491 (1987).
Kriegler et al. “Identification of the “Factor” in Erythrocyte Lysates Which Enhances Colony Growth in Agar Cultures” Exp Hematol 9(1):11-21 (1981).
Krizanac-Bengez et al. “Effect of Enkephalins on Bone Marrow Cells” Biomed Pharmacother 46:367-373 (1992).
Krizanac-Bengez et al. “Naloxone Behaves as Opioid Agonist/Antagonist in Clonal Cultures of Mouse Bone Marrow Cells” Biomed Pharmacother 49:27-31 (1995).
Krizanac-Bengez et al. “Suppressive Effect of Met-Enkephalin on Bone Marrow Cell Proliferation In Vitro Shows Circadian Pattern and Depends on the Presense of Adherent Accessory Cells” Biomed Pharmacother 50:85-91 (1996).
Lathe “Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data Theoretical and Practical Considerations” J Mol Biol 183:1-12 (1985).
Lord et al. “An Inhibitor of Stem Cell Proliferation in Normal Bone Marrow” Br J Haematol 34:441-445 (1976).
Lord et al. “Inhibitor of Haemopoietic CFU-S Proliferation: Assays, Production Sources and Regulatory Mechanisms” In: The Inhibitors of Hematopoiesis (Najman et al., eds.) 162:227-239 (1987).
Lord et al. “Macrophage-Inflammatory Protein Protects Multipotent Hematopoietic Cells from the Cytotoxic Effects of Hydroxyurea In Vivo” Blood 79(10):2605-2609 (1992).
Lord et al. “Sources of Haemopoietic Stem Cell Proliferation: Stimulators and Inhibitors” Blood Cells 6:581-593 (1980).
McCormick et al. “Antigenic Structure of Human Hemoglobin: Delineation of the Antigenic Site (Site 2) Within Region 41-65 of the Alpha Chain by Immunochemistry of Synthetic Peptides” J Prot Chem 4(3):171-184 (1985).
McDonald et al. “Structural, Functional, and Subunit Assembly Properties of Hemoglobin Attleboro[α138 (H21) Ser→Pro], A Variant Possessing a Site Mutation at a Critical C-Terminal Residue” Biochem 29(7):173-178 (1990).
Michel et al. “Removal of Arg141 from the α Chain of Human Hemoglobin by Carboxypeptidases N and M” Circ Res 78(4):635-642 (1996).
Moqattash et al. “Hemopoietic Recovery from AZT Toxicity with Recombinant Hemoglobin in a Murine Model of AIDS” Acta Haematol 92:182-186 (1994).
Mueller et al. “Purified Adult Hemoglobin Stimulates the Proliferation and Differentiation of Erythroid Progenitors” Blood 86(10):496a, Abstract 1974 (1995).
Ohtsuka et al. “An Alternative Approach to Deoxyoligonucleotides as Hybridization Probes by Insertion of Deoxyinosine at Ambiguous Cordon Positions” J Biol Chem 260(5):2605-2608 (1985).
Petrov et al. “Myelopeptides: Bone Marrow Regulatory Mediators” Biosci Rep 15(1):1-14 (1995).
Phillips et al. “Allogeneic Bone Marrow T

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hemoglobin alpha chain peptide fragments useful for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hemoglobin alpha chain peptide fragments useful for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hemoglobin alpha chain peptide fragments useful for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3510293

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.