Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-07
2005-06-07
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S007200, C536S023100, C536S025300, C536S024300, C536S026600
Reexamination Certificate
active
06902895
ABSTRACT:
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.
REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4261968 (1981-04-01), Ullman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4318707 (1982-03-01), Litman et al.
patent: 4650770 (1987-03-01), Liu et al.
patent: 4713348 (1987-12-01), Ullman
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4868104 (1989-09-01), Kura et al.
patent: 4996143 (1991-02-01), Heller et al.
patent: 5225064 (1993-07-01), Henkens et al.
patent: 5284748 (1994-02-01), Mroczkowski et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5360895 (1994-11-01), Hainfield et al.
patent: 5384073 (1995-01-01), Shigekawa et al.
patent: 5384265 (1995-01-01), Kidwell et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5508164 (1996-04-01), Kausch et al.
patent: 5514602 (1996-05-01), Brooks, Jr. et al.
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5571726 (1996-11-01), Brooks, Jr. et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5609907 (1997-03-01), Natan
patent: 5637508 (1997-06-01), Kidwell et al.
patent: 5665582 (1997-09-01), Kauskch et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5830986 (1998-11-01), Merrill et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5922537 (1999-07-01), Ewart et al.
patent: 5939021 (1999-08-01), Hansen et al.
patent: 5972615 (1999-10-01), An et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6025202 (2000-02-01), Natan
patent: 6066448 (2000-05-01), Wohlstadter
patent: 6149868 (2000-11-01), Natan et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6214560 (2001-04-01), Yguerabide et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6264825 (2001-07-01), Blackburn et al.
patent: 6277489 (2001-08-01), Abbott et al.
patent: 6306610 (2001-10-01), Bawendi et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6417340 (2002-07-01), Mirkin et al.
patent: 6518022 (2003-02-01), Sosnowski et al.
patent: 0 630 974 (1994-06-01), None
patent: 0 667 398 (1995-08-01), None
patent: WO 89/06801 (1989-07-01), None
patent: WO 90/02205 (1990-03-01), None
patent: WO 92/04469 (1992-03-01), None
patent: WO 93/10564 (1993-05-01), None
patent: WO 93/25709 (1993-12-01), None
patent: WO 94/29484 (1994-12-01), None
patent: WO 97/40181 (1997-10-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/10289 (1998-03-01), None
patent: WO 98/17317 (1998-04-01), None
patent: WO 99/20789 (1999-04-01), None
patent: WO 99/21934 (1999-05-01), None
patent: WO 99/23258 (1999-05-01), None
patent: WO 99/60169 (1999-11-01), None
patent: WO 00/25136 (2000-05-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/51665 (2001-07-01), None
patent: WO 01/73123 (2001-10-01), None
patent: WO 01/86301 (2001-11-01), None
patent: WO 02/04681 (2002-01-01), None
patent: WO 02/18643 (2002-03-01), None
patent: WO 02/36169 (2002-05-01), None
patent: WO 00/33079 (2002-06-01), None
patent: WO 02/46472 (2002-06-01), None
patent: WO 02/46483 (2002-06-01), None
Mohanty J., et al. “Pulsed laser excitation of phosphate stabilized silver nanoparticles,”Proc. Indian Acd. Sci.,vol. 112, No. 1, p. 63-72.
Peńa-Nicewarner S., et al., “Hybridization and Enzymatic Extension of Au Nanoparticle-Bound Oligonucleotides,”J. Am. Chem. Soc.,vol. 124, p. 7314-7323 (2002).
Whitesides G.M., et al., “Soft Lithography in Biology and Biochemistry,”Annu. Rev. Biomed. Eng.,p. 335-373 (2001).
O.D. Velev, et al., “In Situ Assembly of Collordal Particles into Miniaturized Biosensors,”Langmuir,vol. 15, No. 11, pp. 3693-3698, May 25, 1999.
Stimpson, et al., “Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides,”Proc. Natl. Acad. Sci . . . ,vol. 92, pp. 6379-6383, California Institute of Technology (1995) U.S.
Storhoff, et al., “Strategies for Organizing Nanoparticles into Aggregate Structures and Functional Materials,”Journal of Cluster Science,vol. 8, No. 2, pp. 179-217, Plenum Publishing Corporation (1997) U.S.
Storhoff, et al., “One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticles Probes,”J. Am. Chem. Soc.,vol. 20, pp. 1961-1964, American Chemical Society (1998) U.S.
Velev, et al., “In Situ Assembly of Colloidal Particles into Miniaturized Biosensors,”Langmuir,vol. 15, No. 11, pp. 3693-3698, American Chemical Society (1999) U.S.
Zhu, et al., “The First Raman Spectrum of an Organic Monolayer on a High-Temperature Superconductor: Direct Spectroscopic Evidence for a Chemical Interaction between an Amine and Yba2Cu3O7-8,”J. Am. Chem. Soc.,vol. 119, pp. 235-236, American Chemical Society (1997) U.S.
Yguerabide, et al., “Light-Scattering Submicroscopic Particles as Highly Fluorescent Analogs and Their Use as Tracer Labels in Clinical and Biological Applications,” I. Theory,Analytical Biochemistry,vol. 262, pp. 137-156 (1998) U.S.
Yguerabide, et al., “Light-Scattering Submicroscopic Particles as Highly Fluorescent Analogs and Their Use as Tracer Labels in Clinical and Biological Applications,” II. Experimental Characterization,Analytical Biochemistry,vol. 262, pp. 157-176 (1998) U.S.
Brada, et al., “Golden Blot”—Detection of Polyclonal and Monoclonal Antibodies Bound to Antigens on Nitrocellulose by Protein A-Gold Complexes,Analytical Biochemistry,vol. 42, pp. 79-83 (1984) U.S.
Dunn, et al., A Novel Method to Map Transcripts: Evidence for homology between an Adenovirus mRNA and Discrete Multiple Regions of the Viral Genome,Cell,vol. 12, pp. 23-36, (1997) U.S.
Hacker, High performance Nanogold—Silver in situ hybridisation,Eur. J. Histochem,vol. 42, pp. 111-120 (1998) U.S.
Ranki, et al., “Sandwich hybridization as a convenient method for the detection of nucleic acids in crude samples,”Gene, vol. 21, pp. 77-85 (1983) U.S.
Romano, et al., “An antiglobulin reagent labelled with colloidal gold for use in electron microscopy,”Immunochemistry,vol. 11, pp. 521-522 (1974) Great Britain.
Alivisatos et al., “Organization of ‘nanocrystal molecules’ using DNA,”Nature,vol. 382, pp. 609-611 (1996).
Bain, et al., “Modeling Organic Surfaces with Self-Assembled Monolayers,”Angew. Chem. Int. Ed. Engl.,vol. 28, pp. 506-512 (1989).
Bradley, “The Chemistry of Transition Metal Colloids,”Clusters and Colloids: From Theory to Applications,G. Schmid, Editor, BCH, Weinheim, New York, pp. 459-542 (1994).
Brust et al., “Novel Gold-Dithiol Nano-Networks with Non-Metallic Electronic Properties,”Adv. Mater.,vol. 7, pp. 795-797 (1995).
Chen et al., “A Specific Quadrilateral Synthesized from DNA Branched Junctions,”J. Am. C
Elghanian Robert
Letsinger Robert L.
Mirkin Chad A.
Mucic Robert C.
Storhoff James J.
McDonnell Boehnen & Hulbert & Berghoff LLP
Nanosphere Inc.
Riley Jezia
LandOfFree
Nanoparticles having oligonucleotides attached thereto and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nanoparticles having oligonucleotides attached thereto and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles having oligonucleotides attached thereto and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3509186