N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fuse

Details N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fuse N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fuse

1991-09-25

1993-03-16

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514311, 514312, 514313, 546112, 546153, 546155, 546157, 546158, 546159, 546171, 546183, A61K 3147, C07D51304

Patent

active

051944391

ABSTRACT:
Pyridine derivatives of formula ##STR1## their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0, 1 and 2; R is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, amino, (lower)alkylamino or di(lower)alkylamino; R.sup.1 is hydrogen or lower alkyl; R.sup.2 is --(CH.sub.2).sub.n --R.sup.3 or --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.m --R.sup.3 or --CH.sub.2.C.tbd.C.(CH.sub.2).sub.m --R.sup.3 where n is 1 to 6, and m is 0 to 3; and R.sup.3 is a ring of formula ##STR2## The compounds exhibit activity as 5-HT.sub.1A agonists, antagonists or partial agonists and are used for the treatment of CNS disorders, e.g. anxiety, as antihypertensives and in treating anorexia.

REFERENCES:
patent: 4878941 (1989-11-01), Theodoris
patent: 4894084 (1990-01-01), Theodoris
Ornstein, et al., "Molecular Models", Chem. Biol. Interactions, 30 (1980) 87-103.

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