Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1990-01-17
1991-05-28
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 856, 424 857, A61K 3766
Patent
active
050193821
ABSTRACT:
Neoplastic disease, hyperallergenicity, autoimmune disorders characterized by chronic tissue degenerative inflammation and immuno-resistant viral infections are treated by the administration of interferon at a dosage of about 0.1 to about 5 IU/lb per day by contacting said interferon with oral/pharyngeal mucosa. Interferon is administered in solution or in a novel solid unitary dosage form adapted to be dissolved in saliva when placed in the mouth.
REFERENCES:
patent: 3536809 (1970-10-01), Applezweig
patent: 3906092 (1975-09-01), Hilleman et al.
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 4053582 (1977-10-01), Stickl
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4250163 (1981-02-01), Nagai et al.
patent: 4273703 (1981-06-01), Osther et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4460574 (1984-07-01), Yabrov
patent: 4462985 (1984-07-01), Cummins, Jr.
patent: 4497795 (1985-05-01), Cummins
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4605555 (1988-04-01), Sato et al.
patent: 4649075 (1987-03-01), Jost
patent: 4675184 (1987-06-01), Hasegawa et al.
patent: 4699136 (1987-10-01), Krauser
patent: 4710191 (1987-12-01), Kwiatek et al.
patent: 4713239 (1987-12-01), Babaian et al.
patent: 4746508 (1988-05-01), Carey et al.
patent: 4764378 (1988-09-01), Keith et al.
Sandstrom, Eric, Drugs, vol. 31, pp. 463-466, 1986.
"Stimulation of Humoral Immunity by Interferon", III Mediterranean Congress of Chemotherapy, Smerdel, S., et al., Sep. 21-24, 1982 Presentation, vol. 2, p. 132, Oct. 1983.
"Interferon Preparations as Modifiers of Immune Responses", Braun, W., Levy, H.B., Proc. Soc. Exp. Biol. Med.. vol. 141, pp. 769-773, 1972.
"Interferon and the Immune System: A Review (Limited to Alpha and Beta Interferons)", De Maeyer, Edward, The Biology of the Interferon System, pp. 203-209, Elsevier/North-Holland Biomedical Press, 1981.
"Colorectal Administration of Human Interferon-Alpha", Bocci et al., International Journal of Pharmaceutics, vol. 24, pp. 109-114, 1985.
"Interferon Administered Orally: Protection of Neonatal Mice From Lethal Virus Challenge", Schafer, T., et al., Science, Jun. 23, 1972, vol. 176, pp. 1326-1327.
"Circulating Interferon in Rabbits After Administration of Human Interferon by Different Routes", Cantel, K. and Ryhala, L., Journal of General Virology, (1973), 20, pp. 97-104.
"Pharmacokinetics of Recombinant Alpha A Interferon Following IV Infusion and Bolus, IM, and PO Administrations to African Green Monkeys", Wills, R. J., Spiegel, H. E., and Soikel, K. F., Journal of Interferon Research, vol. 4, No. 3, 1984, pp. 399-409.
"Pharmacokinetics of Recombinant Leukocyte A Interferon Following Various Routes and Modes of Administration to the Dog", Gibson, D. M., et al., Journal of Interferon Research, 5:403-408 (1985).
"Effect of Virus-Induced Interferon On the Antibody Response of Suckling and Adult Mice", Vignauz, F., et al., Eur. J. Immunol., vol. 10, pp. 767-772, 1980.
"The Clinical Use of Human Leukocyte Interferon in Viral Infections", Ikic, D., et al., Internationl Journal of Clinical Pharmacology, Therapy and Toxicology, vol. 19, No. 11, pp. 498-505, 1981.
"Primjena Humanog Leukocitnog Interferona U Male Djece Sa Gingivostomatitisom", Salaj-Rakic, T., et al., Proceedings-Yougoslav-Pediatric Congress, Sarayevo, 1979, p. 730.
Rodder, H., Thumann, D., Thumann, E., Tierarztliche Umschau, vol. 34, No. 10, 1979, pp. 720-724 (Summary).
Toneva, V., Bulletin de l'Office International des Epizooties, vol. 88, 1977, pp. 631-637 (Summary).
"In Vivo and Clinical Studies", Norman B. Finter & Robert K. Oldham, eds., Interferon, vol. 4, 1985, pp. 137, 148, 173, 218, 226, 284, 285, 330, Chemical Abstracts, vol. 67, 1967, p. 7536 [80070u], Litvinov, A. N.
"Time and Dosage Dependence of Immunoenhancement by Murine Type II Interferon Preparations", Cellular Immunology, 40, 1978, pp. 285-293.
"Interferons and Their Actions", W. E. Stewart II and A. A. Gottlieb, eds., 1977, pp. 102-104.
"Antiviral Effect of Bacterially Produced Human Inteferon (Hu-IFNa.sub.2) Against Experimental Vaccinia Infection in Calves", Journal of Interferon Research, 5:129-136, 1985, Werenne, J., Broecke, C. V., Schwers, A., Goossens, A., Bugyaki, L., et al.
"Effect of Human Leukocyte A Interferon on Prevention of Infectious Bovine Rhinotracheitis Virus Infection of Cattle", Roney, C. S. et al., Am J. Vet. Res., vol. 46, No, 6, Jun. 1985, pp. 1251-1255.
"Response of Feline Leukemia Virus-Induced Nonregenerative Anemia to Oral Administration of an Interferon-Containing Preparation", Feline Practice, vol. 12, No. 3, May-Jun. 1982, pp. 6-15, Tompkins, M. B. and Cummins, J. M.
"Interferon Enters the Fray", Farm Journal, Oct. 1985, pp. 12-13, Miller, B.
"Interferon as an Adjuvant for Hepatitis B Vaccinationin Non-and Low-Responder Populations", Grob, P. J. et al., Eur. J. Clin. Microbiol., Jun. 1984, vol. 3, No. 3, pp. 195-198.
"Protection of Calves Against Rhinovirus Infection by Nasal Secretion Interferon Induced by Infectious Bovine Rhinotracheitis Virus", American Journal of Veterinary Research, Cummins, J. M. and Rosenquist, B. D., Feb., 1980, vol. 41, No. 2, pp. 161-165.
"Bovine Respiratory Disease-A Symposium", R. W. Loan, ed., texas A&M University Press, College Station, TX, 1984, pp. 484-485.
"Activity of Exogenous Interferon In the Human Nasal Mucosa", Texas Reports on Biology and Medicine, vol. 35, 1977, Greenberg, S. B., Harmon, M. W. and Johnson, P. E., pp. 491-496.
"Inhibition of Respiratory Virus Infection by Locally Applied Interferon", Merigan, T. C., Hall, T. S., Reed, S. E., and Tyrrell, D. A., The Lancet, Mar. 17, 1973, pp. 563-567.
"Trials of Interferon in Respiratory Infections of Man", Tyrrell, D.A.J., Texas Reports on Biology and Medicine, vol. 35, 1977, pp. 486-490.
"Bacteria-Derived Human Leukocyte Interferons After in Vitro Humoral and Cellular Immune Responses", Cellular Immunology, 82, 1983, pp. 269-281, by Shalaby, M. R. and Weck, P. K.
"Clinical and Laboratory Investigations on Man: Systemic Administration of Potent Interferon to Man", J. Natl. Cancer Inst., 51: 733-742, 1973, by Strander, H., Cantell, K., Carlstrom, G. and Jakobsson, P. A.
"Application of Human Leukocyte Interferon in Severe Cases of Virus B Hepatitis", Vlatkovic, R., et al., Proc. Symposium on Interferon 1979, Yugoslav Academy of Sciences and Arts, Zagreb, pp. 173-183.
"Effect of Interferon on Vaccination in Volunteers", The Lancet, Apr. 28, 1962, pp. 873-875 (Report ot Medical Reserach Council from the Scientific Committee on Interferon).
"Induction of Ocular Resistance to Vaccinia Virus by Typhoid Vaccine: Role of Interferon", Oh, J. O. and Yoneda, C., The Journal of Immunology, vol. 102, No. 1, 1969, pp. 145-154.
"Clinical Trials with Exogenous Interferon: Summary of a Meeting", The Journal of Infections Diseases, vol. 139, No. 1, Jan. 1979, pp. 109-123.
"Some Results and Prospects in the Study of Endogenous and Exogenous Interferon", The Interferson, An International Symposium, Soloviev, V. D., Geo. Rita, ed., Academic Press, 1968, pp. 233-243.
"Influenza and Interferon Research in the Soviet Union-Jan. 1973", The Journal of Infectious Diseases, vol. 128, No. 2, Aug. 1973, pp. 261-264.
"The Results of Controlled Observations on the Prophylaxis of Influenza with Interferon", Solov'ev, V. D., World Health Organization, 1949, 41, 683-688.
"Children's Respiratory Viral Diseases Treated With Interferon Aerosol", Jia-Xiong, D. et al., Chinese Medical Journal, 100(2): 162-166, 1987.
Essential Clinical Virology, R. G. Sommerville, Blackwell Scientific Publications, pp. 154-157.
"Comparative Intranasal Pharmacokinetics of Interferon Using Two Spray Systems", Davies, H. W. et al., J. Interferon Research, 1983, pp. 443-449.
"The Common Cold Control?", Couch, R. B., The Journal of Infectitious Diseases, vol. 150, No. 2, Aug. 1984, pp. 167-173.
Principles and Practice of Infectious Diseases, 2nd. ed., Mandell, G. L., Douglas, R. G. Jr., Bennett, J. E. eds., A Wiley Medical Publication, pp. 85-96, 863, 968.
Antiviral Agents and Viral Diseases of Man, Edited by G. J. Galasso, T. C. Merigan, R. A. Buch
Koh Choon
Schain Howard E.
The Texas A&M University System
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