Heterocyclic containing biphenyl aP2 inhibitors and method

Details Heterocyclic containing biphenyl aP2 inhibitors and method Heterocyclic containing biphenyl aP2 inhibitors and method

2005-08-09

2005-08-09

Shameem, Golam M M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S203000, C548S235000, C548S252000, C548S314700, C548S341100, C514S374000, C514S399000

Reexamination Certificate

active

06927227

ABSTRACT:
aP2 inhibiting compounds are provided having the formulawherein R1, R2, R3, R4, X—Z andare as described herein.A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.

REFERENCES:
patent: 5348969 (1994-09-01), Romine et al.
Krasovitskii et al (1985): STN International, CAPLUS Database (Columbus, Ohio), document No. 103:71231.
Krasovitskii, B.M. et al., “Sterically Hindered Mono- and Bis(2,5-Diaryloxazoles) Containing Biphenyl Systems”, Chemistry of Heterocyclic Compounds, vol. 21, pp. 149-153 (1985) (English translation of Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 184-188, Feb., 1985).
Schlögl, K. et al., “Optisch aktive Tricarbonylchrom-Komplexe der Diphensäure und ihrer Derivate—Enantiomerenreinheit, Circulardichroismus und absolute Konfiguration”, Liebigs Ann. Chem., vol. 11, pp. 1877-1888 (1980).

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