Substituted benzimidazole antiviral agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S257000, C548S259000, C548S260000

Reexamination Certificate

active

06908936

ABSTRACT:
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.

REFERENCES:
patent: 3394141 (1968-07-01), Sparatore
patent: 4324794 (1982-04-01), Tidwell et al.
patent: 5066656 (1991-11-01), Greco et al.
patent: 5256668 (1993-10-01), Hsu et al.
patent: 14704/97 (1997-08-01), None
patent: 0058146 (1982-08-01), None
Pagani, F.; Sparatore, F.; Boll. Chim. Farm, vol. 104, 427-428 (1965).
Paglietti, G.; Boido, V.; Sparatore, F.; II Farmaco—Ed. Sc., vol. 30, 505-507, (1975).
“Update: Respiratory Syncytial Virus Activity-United States, 1996-97 Season,” JAMA, vol. 277, No. 1, pp. 12-13, Jan. 1, 1997.
E. DeClercq, “Perspectives for the Chemotherapy of Respiratory Syncytial Virus (RSV) Infections,” International Journal of Antimicrobial Agents, 7, pp. 193-202, 1996.
R. R. Tidwell, et al, “Aromatic Amidines: Comparison of Their Ability to Block Respiratory Syncytial Virus Induced Cell Fusion and to Inhibit Plasmin, Urokinase, Thrombin, and Trypsin,” J. Med. Chem., 26, pp. 294-298, 1983.
E. J. Dubovi, et al, “Inhibition of Respiratory Syncytial Virus-Host Cell Interactions by Mono- and Diamidines,” Antimicrobial Agents and Chemotherapy, vol. 19, No. 4, pp. 649-656, Apr., 1981.
P. R. Wyde, et al, “CL387626 Exhibits Marked and Unusual Antiviral Activity Against Respiratory Syncytial Virus in Tissue Culture and in Cotton Rats,” Antiviral Research, 38, pp. 31-42, 1998.
F. Pagani, et al, “Benzotriazolil-Alchil-Benzimidazoli E Loro Derivati Dialchil-Amminoalchilici,” Boll. Chim. Farm., 104, pp. 427-431, 1965.
G. Paglietti, et al, “Dialchilamminoalchilbenzimidazoli Di Interesse Farmacologico,” IL Farmaco, Ed. Sci., vol. 30, pp. 505-511, 1975.
F. Sparatore, et al, “Dialchilamminoalchilbenzimidazoli D' Interesse Farmacologico,” IL Farmaco, Ed. Sci., vol. 23, pp. 344-359, 1967.
S. Shigeta, et al, “Inhibitory Effect of Pyridobenzoazoles on Orthomyxo- and Paramyxovirus Replication In Vitro,” Antiviral Chemistry and Chemotherapy, 3(3), 171-177, 1992.
W. R. Roderick, et al, “Bisbenzimidazoles. Potent Inhibitors of Rhinoviruses,” Journal of Medicinal Chemistry, vol. 15, No. 6, pp. 655-658, 1972.
B. Cakir, et al, “Benzimidazole Derivatives: bis-Benzimidazoles and Their Antifungal Activities,” Gazi Ecz. Fak. Der., 5(1), pp. 71-77, 1988.
F. Sparatore, et al, “Derivati Benzotriazolici Attivi Sull'accrescimento Delle Piante,” IL Farmaco, Ed. Sci., 33, pp. 901-923, 1978.
A. R. Katritzky, et al, “Syntheses and Transformations of Substituted Benzazolyl- and Tetrazolyl(Benzotriazol-1-yl)Methanes,” J. Heterocyclic Chem., vol. 33, pp. 1107-1114, 1996.
T. A. Fairley, et al, “Structure, DNA Minor Groove Binding, and Base Pair Specificity of Alkyl- and Aryl- Linked Bis(Amidinobenzimidazoles) and Bis(Amidinoindoles,” J. Med. Chem., 36, pp. 1746-1753, 1993.
R. K. Upadhyay, et al, “New Heterocycles: Synthesis and Biological Evaluation,” Indian Journal of Heterocyclic Chemistry, vol. 4, pp. 121-124, Oct.-Dec. 1994.
A. R. Katritzky, et al, “A New Route to N-Substituted Heterocycles,” TETRAHEDRON, vol. 49, No. 14, pp. 2829-2838, 1993.
E. J. Dubovi, et al, “Inhibition of Respiratory Syncytial Virus by Bis-5-Amidino-2-Benzimidazolyl)Methane,” VIROLOGY, 103, pp. 502-504, 1980.

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