Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-01
2005-11-01
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S058200, C540S544000, C540S598000, C540S575000, C514S227500, C514S227800, C514S217050, C514S218000
Reexamination Certificate
active
06960575
ABSTRACT:
A compound having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine 4-tetrahydropyrazine as a main skeleton. The compound is a chymase inhibitor and is represented by the following formula [I] and salts thereof:In the formula [I], X is S; R1and R2are H, alkyl, cycloalkyl or aryl; R3and R4are H, alkyl, cycloalkyl, aryl or an aromatic heterocycle; R5is H, alkyl, cycloalkyl, aryl or -A3-A4-R7; R6is H, alkyl, cycloalkyl, hydroxy, alkoxy, aryl, aryloxy or an aromatic heterocycle; R7is H, alkyl, hydroxy, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, an aromatic heterocycle or a nonaromatic heterocycle; A1is alkylene; A2is carbonyl or sulfonyl; A3is alkylene; A4is carbonyl or oxalyl; and n is 0 or 1.
REFERENCES:
patent: 5908843 (1999-06-01), Gante et al.
patent: 6211183 (2001-04-01), Marlowe et al.
patent: 0 608 759 (1994-08-01), None
patent: 0 643 072 (1995-03-01), None
patent: 0 666 261 (1995-08-01), None
patent: 58-35176 (1983-03-01), None
patent: 2-275869 (1990-11-01), None
patent: WO 98/46591 (1998-10-01), None
{Takai S, Jin D, and Miyazaki M., Abstract of Nippon Yakurigaku Zasshi, Oct. 1999; 114 Suppl 1:41p-47P}.
Takai, S., Jin D., and Miyazaki M., Abstract of Nippon Yakurigaku Zasshi, Oct. 1999; 114, Suppl. 1:41P 47P.
Ban Masakazu
Fujimura Ken-ichi
Honda Takahiro
Hori Masanori
Kobayashi Naoyuki
Berch Mark L.
Habte Kahsay
Santen Pharmaceutical Co. Ltd.
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