Method for the preparation of citalopram

Details Method for the preparation of citalopram Method for the preparation of citalopram

2005-02-01

2005-02-01

Wang, Shengjun (Department: 1617)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S469000

Reexamination Certificate

active

06849749

ABSTRACT:
A method for the preparation of citalopram comprising reductive hydrolysis of a compound of Formula (IV):wherein R is a N,N-disubstituted amid group or an optionally substituted 4,5-dihydro-1,3-oxazol-2-yl group, and conversion of the resulting 5-formyl compound to citalopram.

REFERENCES:
patent: 4136193 (1979-01-01), Bogeso et al.
patent: 6162942 (2000-12-01), Rock et al.
patent: 6310222 (2001-10-01), Ikemoto et al.
patent: 6331628 (2001-12-01), Kondo et al.
patent: 6365747 (2002-04-01), Dall'Asta et al.
patent: 6392060 (2002-05-01), Petersen et al.
patent: 6403813 (2002-06-01), Petersen et al.
patent: 6426422 (2002-07-01), Petersen et al.
patent: 6433196 (2002-08-01), Ikemoto et al.
patent: 20020026062 (2002-02-01), Petersen et al.
patent: 20020087012 (2002-07-01), Castellin et al.
patent: 20020120005 (2002-08-01), Villa et al.
patent: 20020128497 (2002-09-01), Bolzonella et al.
patent: 20020198391 (2002-12-01), Petersen et al.
patent: 20030013895 (2003-01-01), Petersen
patent: 20030050484 (2003-03-01), Petersen
patent: 20030060640 (2003-03-01), Petersen
patent: 20030060641 (2003-03-01), Petersen et al.
patent: 20030069304 (2003-04-01), Petersen
patent: 20030078442 (2003-04-01), Petersen et al.
patent: 20030083508 (2003-05-01), Petersen et al.
patent: 20030083509 (2003-05-01), Petersen et al.
patent: 20030092761 (2003-05-01), Rock et al.
patent: 20030092919 (2003-05-01), Petersen
patent: WO 9819513 (1998-05-01), None
patent: WO 0102383 (2001-01-01), None
patent: WO 0185712 (2001-11-01), None
patent: WO 03011278 (2003-02-01), None
Harrison et al., Compendium of Organic Synthetic Methods, 1971 pp. 148 and 461.*
Huber, Vincent J. et al., “Preparation of Nitriles from Carboxylic Acids: A New, Synthetically Useful Examples of the Smiles Rearrangement,”Tetrahedron54: 9281-9288 (1998).
Buehler, Calvin A. et al.,Survey of Organic Synthesis: 951, New York: Wiley-Interscience (1979).
U.S. Appl. No. 09/930,107, filed Aug. 14, 2001.
Levy, L.F., “4-Aminophthalide and Some Derivatives”,J. Chem. Soc. pp. 867-870, (1931).
Tirouflet J., “Phtalide Substitutes en 5”,Bull. Soc. Sci. de Bretagne, 26:35-43 (1951).
Bigler et al., “Quantitive structure-activity relationships in a series of selective 5-HT uptake inhibitors,”Eur. J. Med. Chem. 12, 3: 289-295 (1997).
U.S. Appl. No. 09/794,762, filed Feb. 26, 2001.
U.S. Appl. No. 09/794,755, filed Feb. 26, 2001.
U.S. Appl. No. 09/830,109, filed Jun. 1, 2001, (International filing date).
U.S. Appl. No. 09/888,067, filed Dec. 22, 1999 (International filing date).
U.S. Appl. No. 09/891,874, filed Oct. 25, 1999, (International filing date).
U.S. Appl. No. 09/917,180, filed Jan. 26, 2000, (International filing date).
U.S. Appl. No. 09/692,653, filed Oct. 18, 2000.
U.S. Appl. No. 09/930,107, filed Aug. 14 , 2001.
U.S. Appl. No. 09/930,110, filed Aug. 14 , 2001.
Levy, L.F., “4-Aminophthalide and Some Derivatives”,J. Chem. Soc, pp. 867-870, (1931).
Tirouflet J., “Phtalide Substitutes en 5”,Bull. Soc. Sci. de Bretagne, 26:35-43 (1951).
Perregaard, Jens et al., “σ Ligands with Subnanomolar Affinity and Preference for the σ2Binding Site 1. 3-(ω-Aminoalkyl)-1 H-indoles,”J. Med. Chem. 38:1998-2008 (1995.

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