Chimeric human papillomavirus (HPV) L1 molecules and uses...

Details Chimeric human papillomavirus (HPV) L1 molecules and uses... Chimeric human papillomavirus (HPV) L1 molecules and uses...

2005-06-21

2005-06-21

Salimi, Ali R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C424S204100, C435S069100, C435S069700, C530S300000

Reexamination Certificate

active

06908613

ABSTRACT:
Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.

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Steller M. A. , Current Opinion in Investigational Drugs, 2002, vol. 3, No. 1, pp. 37-47.
Zhang, et al., “HPV6b virus like particles are potent immunogens without adjuvant in man”,Vaccine18 (2000), 1051-1058.

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