Peptides conferring environmental stress resistance and...

Details Peptides conferring environmental stress resistance and... Peptides conferring environmental stress resistance and...

2005-02-22

2005-02-22

Wax, Robert A. (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S300000, C530S326000, C530S327000, C530S328000

Reexamination Certificate

active

06858704

ABSTRACT:
The present invention relates to peptides comprising at least one sequence selected from the group consisting of oligopeptide sequences of at least about 10 but not more than about 50 continuous amino acid residues in the amino acid sequence of the C-terminal acidic tail (ATS), which can render fusion partner proteins environmental stress resistant by binding thereto while conserving their intrinsic properties. Also, it relates to fusion proteins formed by binding the above peptides to fusion partner proteins, nucleotide sequences encoding said fusion proteins, recombinant vectors comprising said nucleotide sequences, and cells transformed or transfected with said recombinant vectors. In addition, it relates to processes for producing the above environmental stress resistance conferring peptides or environmental stress resistant fusion proteins by chemical synthesis or genetic recombination.

REFERENCES:
patent: 20020048763 (2002-04-01), Penn et al.
Kanda et al., Enhanced Vulnerability to Oxidative Stress by alpha-synuclein Mutations and C-Terminal Truncation, Neuroscience, 2000, 97(2):279-284.
Kim et al., Structural Changes in alpha-synuclein Affect its Chaperone-like Activity in vitro, Protein Science, 2000, 9:2489-2496.
Kim et al., Thermal Behavior of Proteins: Heat-Resistant Proteins and Their Heat-Induced Secondary Structural Changes, Biochemistry, 2000, 39:14839-14846.
Souza et al., Chaperone-like Avtivity of Synucleins, FEBS Letters, 2000, 474:116-119.

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