Novel methods and compositions for treatment of angiogenic disea

Details Novel methods and compositions for treatment of angiogenic disea Novel methods and compositions for treatment of angiogenic disea

1989-12-27

1992-02-04

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530327, A61K 3702, C07K 710, C07K 708

Patent

active

050861646

ABSTRACT:
The subject invention pertains to the use of recombinant PF4 (rPF4) as well as full length novel analogs (mutants) of rPF4, and peptide fragments thereof, to inhibit angiogenesis. rPF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation.

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patent: 4737580 (1988-04-01), Twardzik et al.
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Folkman, J., (1984), "Angiogenesis: Initiation and Modulation", in Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects, G. L. Nicolson and L. Milas, eds., Raven Press, New York, pp. 201-208.
Taylor, S., J. Folkman, (1982), "Protamine is an Inhibitor of Angiogenesis", Nature, 297:307-312.
Deuel, T. F., R. M. Senior, D. Chang, G. L. Griffin, R. L. Heinrikson, E. T. Kaiser, (1981), "Platelet Factor 4 is Chemotactic for Neutrophils and Monocytes", Proc. Natl. Acad. Sci. USA, 78:4585-4587.
Osterman, D. G., G. L. Griffin, R. M. Senior, E. T. Kaiser, T. F. Deuel, (1982), "The Carboxyl-Terminal Tridecapeptide of Platelet Factor 4 is a Potent Chemotactic Agent for Monocytes", Biochem. and Biophys. Res. Comm., 107(1):130-135.
Wolpe, S. D., A. Cerami, (1989), "Macrophage inflammatory Proteins 1 and 2: Members of a Novel Superfamily of Cytokines", the FASEB Journal, 3:2565-2573.

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