Method and means for detecting inflammatory processes

Details Method and means for detecting inflammatory processes Method and means for detecting inflammatory processes

2005-11-08

2005-11-08

Jones, Dameron L. (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S001370, C424S001650, C424S009100

Reexamination Certificate

active

06962687

ABSTRACT:
A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido-15N2]-arginine, L-[guanido-15N]-arginine, their mixtures and pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier; (b) collecting a sample of exhaled air, saliva or urine; (c) determining13NO in the air sample or its transformation products15IN-nitrite and/or15N-nitrate in the saliva sample or urine. Also disclosed is a corresponding diagnostic composition for use in diagnosing inflammatory processes and a method for its manufacture.

REFERENCES:
patent: 6379649 (2002-04-01), Katsifis et al.
patent: 19719098 (1999-05-01), None
patent: WO 96/17244 (1996-06-01), None
patent: WO 97/37587 (1997-10-01), None
Forte et al, Hypertension (1998), 32(4) 730-734.
Forte et al., “Measurement of Nitric Oxide Synthesis in Humans Using L-[15N2]Arginine”, Methods in Enzymology, vol. 301, pp. 92-98 (1999).

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