Sustained-release microencapsulated delivery system

Details Sustained-release microencapsulated delivery system Sustained-release microencapsulated delivery system

2005-10-11

2005-10-11

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000, C424S490000, C424S491000, C424S498000

Reexamination Certificate

active

06953593

ABSTRACT:
Disclosed is a process for producing sustained-release powders that is fast, efficient, and economical. The process involves melting an animal or vegetable oil with a melting point above 110 degrees F. in specially designed mixer through either the work energy input of the mixer shaft itself, or a specially fitted plow type mixer equipped with a heating tank, cooling unit, jacket for hot water circulation, and heated lines with nozzles for atomizing the hot oil to be sprayed on. The entire manufacturing process can be completed in about 5-30 minutes, and results in small, sustained-release particles that are free flowing and solid at room temperature. The preferred oil is a hydrogenated soy oil with a melting point range of 145-160 degrees F. which is applied at about a 5% level by weight in a high shear mixer. Also included are sustained-release compositions for therapeutic agents such as drugs, botanicals, biological agents, fungicides, and fertilizers.

REFERENCES:
patent: 4837381 (1989-06-01), Steber et al.
patent: 5494681 (1996-02-01), Cuca et al.
patent: 5756719 (1998-05-01), Chaundy et al.
patent: 5849240 (1998-12-01), Miller et al.
patent: 5958452 (1999-09-01), Oshlack et al.
patent: 6048562 (2000-04-01), Mandralis et al.

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