Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2005-02-01
2005-02-01
Le, Long V. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C436S524000, C435S007100, C435S285200, C435S288400, C422S051000, C422S051000, C422S068100, C422S105000, C604S890100
Reexamination Certificate
active
06849463
ABSTRACT:
Microchip devices and methods of use are provided for the controlled exposure of a secondary device. In one embodiment, the microchip device include a substrate, a plurality of reservoirs in the substrate, a secondary device in one or more of the reservoirs, at least one barrier layer covering each of the reservoirs to isolate the secondary device from an environmental component outside the reservoirs, wherein the barrier layer is impermeable to the environmental component, and a microprocessor-controlled actuation means for rendering the barrier layer porous or permeable to the environmental component to expose the secondary device to said environmental component. The secondary device can comprise a sensor or sensing component (e.g., a biosensor). In other embodiments, microchip devices are provided for the controlled exposure of a reacting component, such as an enzyme. In still other embodiments, sensors are provided on the device outside of the reservoirs.
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Langer Robert S.
Santini, Jr. John T.
Sheppard, Jr. Norman F.
Young Chung Chang
Counts Gary W.
Le Long V.
MicroCHIPS, Inc.
Sutherland & Asbill & Brennan LLP
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