Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-04-25
1992-02-04
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514411, 544252, A01N 4354, A01N 43647, A61K 31505, C07D23970
Patent
active
050860577
ABSTRACT:
Compounds of formula (I): ##STR1## [in which: Y represents a group of formula ##STR2## the dotted line is a double of single bond; R.sup.1 is hydrogen, alkyl or aryl; R.sup.2 is hydrogen or halogen; R.sup.3 is alkyl or cycloalkyl; R.sup.4 is hydrogen, alkyl, hydroxy or halogen; and R.sup.6 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or aralkyl;]
and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia. Certain of these compounds are novel.
REFERENCES:
patent: 4007189 (1977-02-01), Sato et al.
patent: 4619933 (1986-10-01), Stringfellow et al.
Sato et al.--"Studies on Cardiovascular Agents, 6, Synthesis and Coronary Vasodilating and Antihypetensive Activities of 1, 2, 4-Triazolo[1,5-a]pyrimidines Fused to Heterocyclic Systems",--J. Med. Chem. 23, 1927-1938 (1980) pp. 927-937.
Ohsuri Jun
Sasagawa Kazuhiko
Shimoji Yasuo
Takiguchi Yo
Azpuru C.
Page Thurman K.
Sankyo Company Limited
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