Peptides modulating activities of heparin other...

Details Peptides modulating activities of heparin other... Peptides modulating activities of heparin other...

2005-02-15

2005-02-15

Canella, Karen A. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S328000, C530S329000

Reexamination Certificate

active

06855801

ABSTRACT:
The present invention involves peptides of various sequences and sizes and methods of using said peptides with a strong affinity for glycosaminoglycans and proteoglycans, wherein said peptides interact strongly with heparin, other glycosaminoglycans, or proteoglycans (PGs).

REFERENCES:
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Matthews, B. “Genetic and Structural Analysis of the Protein Stability Problem”, In: Perspectives in Biochemistry, Neurath, Ed. 1989, American Chemical Society.*
Verrechio A et al. (2000), “Design of peptides with high afinities for heparin and endothelial cell proteoglycans,”J. Biol. Chem.275: 7701-7707.
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Margalit H et al. (1993), “Comparative Analysis of Structurally Defined Heparin Binding Sequences Reveals a Distinct Spatial distribution of Basic Residues,”J. Biol. Chem.268: 19228-19231.
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Hileman RE et al. (1998), “Glycosaminoglycan-protein Interactions; Definition of Consensus Sites in Glycosaminoglycan Binding Proteins,”BioEssays20:156-157.

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