Phenyl naphthol ligands for thyroid hormone receptor

Details Phenyl naphthol ligands for thyroid hormone receptor Phenyl naphthol ligands for thyroid hormone receptor

2005-10-04

2005-10-04

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S054000, C514S369000, C514S532000, C514S534000, C514S535000, C514S563000, C514S565000, C514S569000, C514S592000

Reexamination Certificate

active

06951844

ABSTRACT:
New thyroid receptor ligands are provided which have the general formula IwhereinR1is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C1-6alkyl, or substituted or unsubstituted C3-7cycloalkyl;R2and R3are each independently hydrogen, halogen, substituted or unsubstituted C1-4alkyl, or substituted or unsubstituted C3-6cycloalkyl, wherein at least one of R2and R3is other than hydrogen;R4is a carboxylic acid selected from the group consisting of (CH2)nCOOH, (CH)2COOH, NHCO(CH2)nCOOH, CONH(CH2)nCOOH and NH(CH2)mCOOH;n is an integer from 0 to 4; andm is an integer from 1 to 4.In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T3regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.

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