Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2005-02-01
2005-02-01
Wax, Robert A. (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
06849717
ABSTRACT:
Nematodes, such asCaenorhabditis elegans,that express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in the diseases, to identify mutations involved in the diseases, and to screen for drugs that affect PKD. Behaviors controlled by the action of the genes or gene products are identified and used in the assays. Hence an animal model is provided that permits study of the etiology of polycystic kidney disease and provides a tool to identify the genes involved in the disease pathway, and to identify compounds that may be used to treat or alter the disease progression, lessen its severity or ameliorate symptoms. The nematode genes that encode protein products, mutants of the genes, vectors that contain the genes and mutant genes and nematode strains that contain the vectors are also provided.
REFERENCES:
patent: 4568639 (1986-02-01), Lew
patent: 4756908 (1988-07-01), Lew
patent: 5196333 (1993-03-01), Chalfie et al.
patent: 5472871 (1995-12-01), Wood et al.
patent: 5559026 (1996-09-01), Price et al.
patent: 5741668 (1998-04-01), Ward et al.
patent: 5789189 (1998-08-01), Woo
patent: 5840540 (1998-11-01), St. George-Hyslop et al.
patent: 5891628 (1999-04-01), Reeders et al.
patent: 5929207 (1999-07-01), Horvitz et al.
patent: 5962301 (1999-10-01), Horvitz et al.
patent: 5972882 (1999-10-01), Gattone, II
patent: 5985830 (1999-11-01), Acott et al.
patent: 5986054 (1999-11-01), St. George-Hyslop et al.
patent: 9534573 (1995-12-01), None
patent: 9638555 (1996-12-01), None
patent: 9937770 (1999-07-01), None
Aroian et al., Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function,The EMBO Journal13(2):360-366 (1994).
Aroian et al., The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily,Nature348:393-699 (1990).
Aroian et al., Multiple Functions of let-23, a Caenorhabditis elegans Receptor Tyrosine Kinase Gene Required for Vulval Induction,Genetics128:251-267 (1991).
Bargmann, Neurobiology of the Caenorhabditis elegans Genome,Science282:2028-2033 (1998).
Barr et al., A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans,Nature401:386-389 (1999).
Brenner, The Genetics of Caenorhabditis Elegans,Genetics77:71-94 (1974).
Bronner-Fraser, M. and P.W. Sternberg, Pattern formation and development mechanisms: The cell biological basis of inductive signaling,Curr. Opin. Genet. Dev. 10:347-9 (2000).
Brundage et al., Mutations in a C. elegans G8β Gene Disrupt Movement, Egg Laying, and Viability,Neuron16(5):999-1009 (1996).
Carraway et al., Mucin Structure and Function: Insights from Molecular Biology,Trends in Glycoscience and Glycotechnology7(33):31-44 (1995).
Chalfie et al., Green Fluorescent Protein as a Marker for Gene Expression,Science263:802-805 (1994).
Chamberlin et al., Characterization of Seven Genes Affecting Caenorhabditis elegans Hindgut Development,Genetics153(2):731-742 (1999).
Chamberlin et al., The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans,Development120:2713-2721 (1994).
Chamberlin et al., The PAX gene egl-38 mediated developmental patterning in caenorhabditis elegans,Developmetn124(20):3919-3928 (1997).
Chamberlin et al., Multiple cell interactions are required for fate specification during male spicule development in Caenorhabditis elegans,Development118(2):297-324 (1993).
Chang et al., Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia,Current Biology9(5):237-246 (1999).
Chang et al., C. elegans vulvua development as a model system to study the cancer biology of EGFR signaling,Cancer and Metastatis Reviews18:203-13 (1999).
Chang et al., Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals,The EMBO Journal19(13):3283-94 (2000).
Chen et al., Polycystin-L is a calcium-regulated cation channel permeable to calcium ions,Nature401:383-386 (1999).
Clandinin et al., Inositol Trisphosphate Mediates a RAS-independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. elegans,Cell92(4):523-533 (1998).
Clandinin et al.,Caenorhabditis elegansHOM-C Genes Regulate the Response of Vulval Precursor Cells to Inductive Signal,Developmental Biology182(1):150-161 (1997).
Collet et al., Analysis of osm-6, a Gene That Affects Sensory Cilium Structure and Sensory Neuron Function in Caenorhabditis elegans,Genetics148:187-200 (1998).
Daoust et al., Evidence for a Third Genetic Locus for Autosomal Dominant Polycystic Kidney Disease,Genomics25:733-736 (1995).
Database Embl Nucleotide and Protein Sequences, Nov. 9, 1999, XP002140196 Hinxton, GB AC=AL132862. Caenorhabditis elegans cosmid Y73F8A. From nt 1605-9677.
Database Embl Nucleotide and Protein Sequences. Nov. 1, 1996, XP002140195 Hinxton, GB AC=Q21027. Similar to Glycoproteins. F59A6.3. Caenorhabditis elegans abstract.
Database Embl Nucleotide and Protein Sequences, Mar. 1, 1995, XP002140194 Hinxton, GB AC=Z48544, Caenorhabditis elegans cosmid ZK945. Polysystic kidney disease protein1. From nt 24444 to nt 25742.
Driscoll et al., Mechanotransduction,C. elegans II, pp. 645-677 (1997).
Ebert et al., A Moloney MLV-Rat Somatotropin Fusion Gene Produces Biologically Active Somatotroopin in a Transgenic Pig,Molecular Endocrinology2:277-83 (1988).
Emmons et al., Mating, channels and kidney cysts,Nature401:339-340 (1999).
Félix et al., Symmetry breakage in the development of one-armes gonads in nematodes,Development122(7):2129-2142 (1996).
Félix et al., A gonad-dervied survival signal for vulval precursor cells in two nematode species,Curr. Biol. 8(5):287-290 (1998).
Félix et al., Evolution of Vulva Development in the Cephalobina (Nematoda)k,Developmental Biology221:68-86 (2000).
Ferguson et al., A genetic pathway for the specification of the vulval cell lineages of Caenorhyabditis elegans,Nature326:259-267 (1987).
Gabow et al. Polycyctic Kidney Disease,Diseases of the KidneySchrier, R.W. and C.W. Gottschalk (eds.) 1993.
Gabow, Autosomal Dominant Polycystic Kidney Disease—More Than a Renal Disease,American Journal of Kidney Diseases16(5):403-413 (1990).
Germino et al., The Gene for Autosomal Dominant Polycystic Kidney Disease Lies in a 750-kb CpG-Rich Region,Genomics13:144-151 (1992).
Golden et al., The Roles of SH2/SH3 Domains in Nematode Development,Bioessays14(7):481-484 (1992).
Hajdu-Cronin et al., Antagonism between Goα and Gqα in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goα signaling and regulates Gaα activity ,Genes&Development13(14):1780-1793 (1999).
Hammer et al., Genetic Engineering of Mammalian Embryos,J. Amin. Sci. 63:269-78 (1986).
Han et al., C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation,Nature363(6425):133-140 (1993).
Han et al., Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene,Genes&Development5(12A):2188-2198 (1991).
Han et al., The let-60 Locus Controls the Swtich Between Vulval and Nonvulval Cell Fates in Caenorhabditis elegans,Genetics126:899-913 (1990).
Herskowtiz, Functional inactivation of genes by dominant negative mutations,Nature329:219-222 (1987).
Hill et al., The gene lin-3 encodes an inductive signal for vulval development in C. elegans,Nature358(6386):470-476 (1992).
Hill et al., Cell fate patterning during C. elegans vulval development,Developmentpp. 9-18 (1993).
Himmelbauer et al., Human-Mouse Homologies in the Region of the Polycystic Kidney Disease Gene (PKD1),Genomics13:35-38 (1992).
Hodgkin, Male Phenotypes and Mating Efficiency in Caenorhabditis elegans,Genetics103:43-64 (1983).
Hodgkin, Sexual Dimorphism and Sex Determination,The Nematode C. elegans, pp. 243-279 (1988).
Hoffmann et al., Learning about cancer genes through invertebrate genetics,Curr, Opin. Genet. Dev.
Barr Maureen M.
Sternberg Paul W.
California Institute of Technology
Gray Cary Ware & Freidenrich LLP
Wax Robert A.
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