Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-11-15
2005-11-15
Scheiner, Laura (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S005000, C435S235100, C424S189100, C424S204100, C424S228100, C530S300000, C530S403000, C436S501000
Reexamination Certificate
active
06964852
ABSTRACT:
The invention concerns a structural peptide, identified by antibodies directed against a polypeptide, comprising the 2-45 amino acid sequence of the N-terminal end of the Core or nucleocapsid (p21) protein of the hepatitis C virus (HCV), excluding any protein or peptide compound comprising or consisting of the N-terminal end. The invention is characterized in that it comprises a tertiary structure consisting of at least a first peptide fragment having a secondary structure in α helix, a second peptide fragment having secondary structure in α helix and a third peptide bond fragment linking the two α helices, these two α helices being substantially perpendicular to each other in space. This peptide can be used for detecting antibodies directed against the p21 protein of HCV, for detecting all of part of the RNA of HCV and for preparing a diagnostic, prophylactic or therapeutic composition for detecting, preventing or treating an HCV infection.
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Dalbon Pascal
Jolivet Michel
Lacoux Xavier
Ladaviere Laurent
Penin Francois
Bio Merieux
Oliff & Berridg, PLC
Scheiner Laura
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