Microcapsule matrix microspheres, absorption-enhancing...

Details Microcapsule matrix microspheres, absorption-enhancing... Microcapsule matrix microspheres, absorption-enhancing...

2005-02-01

2005-02-01

Acquah, Samuel A. (Department: 1711)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C264S004300, C264S004320, C264S004400, C264S004700, C264S013000, C428S402240, C428S403000, C424S457000, C424S458000, C424S460000, C424S461000, C424S462000, C424S489000

Reexamination Certificate

active

06849271

ABSTRACT:
The present invention relates to microspheres, processes for the manufacture of said microspheres, pharmaceutical compositions comprising said microspheres, and sustained release methods of administering an effective pharmaceutical amount of a bioactive compound to a subject. The microspheres of the present invention comprise a water insoluble organic matrix comprising an interior region, throughout which are homogeneously dispersed a plurality of microcapsules consisting essentially of a core of bioactive compound coated with material containing charged organic groups and a surface region substantially free of said bioactive compound.

REFERENCES:
patent: 5496565 (1996-03-01), Heinze et al.
patent: 6294195 (2001-09-01), Oshlack et al.
patent: 20010018072 (2001-08-01), Unger

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