Inhibitors of cruzipain and other cysteine proteases

Details Inhibitors of cruzipain and other cysteine proteases Inhibitors of cruzipain and other cysteine proteases

2005-10-25

2005-10-25

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S470000, C549S033000, C549S465000, C549S466000

Reexamination Certificate

active

06958358

ABSTRACT:
Compounds of general formula (I):wherein R1, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.

REFERENCES:
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Fenwick, et al., “Diastereoselective Synthesis, Activity and Chiral Stability of Cyclic Alkoxyketone Inhibitors of Cathepsin K,”Bioorganic&Medicinal Chemistry Letters, vol. 11, pp. 199-202 (2001).
Marquis, et al., “Conformationally Constrained 1, 3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin K,”J. Med. Chem., vol. 41, pp. 3563-3567 (1998).

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