High efficient delivery of a large therapeutic mass aerosol

Details High efficient delivery of a large therapeutic mass aerosol High efficient delivery of a large therapeutic mass aerosol

2005-02-22

2005-02-22

Hartley, Micheal G. (Department: 1616)

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

C424S489000, C424S499000, C424S046000, C514S002600, C514S012200, C514S013800

Reexamination Certificate

active

06858199

ABSTRACT:
A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.

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