Sustained release pharmaceutical preparations containing an anal

Details Sustained release pharmaceutical preparations containing an anal Sustained release pharmaceutical preparations containing an anal

1989-04-12

1992-02-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424468, 424469, 424470, 424480, 514853, A61K 922, A61K 924

Patent

active

050858653

ABSTRACT:
An orally administrable sustained-release pharmaceutical tablet having at least two layers, which are directly compressible, is disclosed. The first layer, an immediate-release layer, contains an orally active analgesic and is readily susceptible to disintegration in the stomach. The second layer, a sustained-release layer which is directly compressed onto the first layer, comprises an orally active decongestant admixed with a major amount of a sustained-release agent so as to display increased resistance to disintegration and erosion in the gastro-intestinal tract relative to the first layer.

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The Theory and Practice of Industrial Pharmacy, 2nd Ed., Lea & Febiger, Phil. U.S.A., 1976, pp. 343, 344.
Formulating For Controlled Release with METHOCEL Cellulose Ethers, Form No. 192-1029-387, The Dow Chemical Company, Dow Chemical U.S.A., Specialty Chemical Department (1987).

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