Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2005-12-20
2005-12-20
Brumback, Brenda (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S236100, C424S239100, C435S252700, C514S002600, C514S012200, C530S350000
Reexamination Certificate
active
06977080
ABSTRACT:
Methods for treating cardiac muscle disorders, such as cardiac arrhythmias, by administration of a neurotoxin to cardiac muscle are disclosed. Bradycardia can be alleviated for several months by a single intrapericardial or intracardiac injection or infusion of a botulinum toxin. Tachycardia can be alleviated by preganglionic sympathetic nervous system administration of a botulinum toxin.
REFERENCES:
patent: 5766605 (1998-06-01), Sanders et al.
patent: 5865794 (1999-02-01), Castro
patent: 6623742 (2003-09-01), Voet
patent: 6767544 (2004-07-01), Brooks et al.
patent: 6869610 (2005-03-01), Aoki et al.
Johnson, Eric. Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteins. Annu Rev Microbiol 53: 551-575, 1999.
Schmitt et al. Bacterial toxins: friends or foes? Emerg Infect Dis 5(2): 224-234, 1999.
Tsuboi et al. Botulinum neurotoxin A blocks cholinergic ganglionic neurotransmission in the dog heart. Jpn J Pharmacol 89(3): 249-254, 2002.
Tsuboi et al. Inotropic, chronotropic, and dromotropic effects mediated via parasympathetic ganglia in the dog heart. Am J Physiol Heart Circ Physiol 279: H1201-H1207, 2000.
Mangrum et al. The evaluation and management of bradycardia. N Eng J Med 342(10): 703-709, 2000.
Dickson, E.,Studies on the Manner in which the Toxin of Clostridium Botulinum Acts Upon the Body, J. Exper Med 37: 711-31 (1923) d.
Fauci, A.,Harrison's Principles of Internal Medicinefourteenth edition (1997), McGraw Hill.
Nattel, S.,Comparative Mechanisms of Acton of Antiarrhythmic Drugs, Am J. Cardiol, 72: 13F-17F (1993).
Wit, A.,Electrophysiological Basis for Antiarrhythmic Drug Action, Clin. Physiol. Biochem. 3: 127-134 (1985).
Waxman, S.,Persistent Primary Coronary Dilation Induced by Transatrial Delivery of Nitroglycerin in to the Pericardial Space: A Novel Approach for Local Cardiac Drug Delivery, J AM Coll Cardiol 33: (7); 2073-2077 (1999).
Claus, D.,Botulinum Toxin: Influence on Respiratory Heart rate Variation, Mov Disord 10(5): 574-9 (1995).
Nebe, A.,No Effects on Heart-Rate Variability and Cardiovascular Reflex Tests After Botulinum Toxin Treatment of Cervical Dystonia, Mov Disord; 11 (3): 337-9 (1996).
Laham, R.,Therapeutic Myocardial Angiogenesis Using Percutaneous Intrapericardial Drug Delivery, Clin Cardiol; 22 (supp 1): 16-19 (1999).
Laham, R.,Subxyphoid Access of the Normal pericardium: A Novel Drug Delivery Technique, Cath&Cardiovasc Inter 47:109-111 (1999).
Sonobe, T.,Development of Intracoronary Local Adhesive delivery Technique, Int. J Artic Organs 20(6); 319-326 (1997).
Avitall, B.,Iontophoretic Transmyocardial Drug Delivery. A Novel Approach to Antiarrhythmic Drug Therapy, Circulation 85: 1582-93 (1992).
Labhasetwar V.,Epicardial Administration of Ibutilide from Polyurethane Matrices: Effects on Defibrillation Threshold and Electrophysiologic ParametersJ Cardiovasc Pharmacol 24: 826-40 (1994).
Lambert, C.,Local Drug Delivery, Cath & Cardiovasc Diagn 41: 231 (1997).
Glazier, J.,Site-Specific Intracoronary Thombolysis With Urokinase-Coated Hydrogel Balloons: Acute and Follow-Up Studies in 95 Patients, Cath & Cardiovasc Diagn 41: 246-253 (1997).
Bartorelli, A.,Local Heparin Delivery Prior to Coronary Stent Implantation: Acute and Six Month Clinical And Angiographic Results, Cath & Cardiovasc Diagn 42: 313-320 (1997).
Nebe, A.,Influence of Botulinum Toxin Type A on the Heart Rate Variability in Patients with Cervical Dystonia, Mov Dis 10; 3: 389 (1995).
Claus, D.,Distant Effects of Botulinum Toxin on Autonomic Cardiac Reflexes, Mov Dis 10: 3: 389 (1995).
Thomas, C.,Local Intracoronary Heparin Delivery With a Microporous Balloon Catheter, Amer Heart J 132; 5: 969-972 (1996).
Camemzind, E.,Site-Specific Intravascular Administration of drugs: History of a Method Applicable in Humans, Cath & Cardiovasc Diagn 41: 342-347 (1997).
Galardi et al.: “The Local Injection of Botulinum Toxin Can Effect the Neural Control of Heart Rate Variability.”, Nerology, vol. 44, 1994, pp. A307-A308.
Kimura et al.; “Negative Chronotropic Effect of Botulinum Toxin on Neonatal Rat Cardiac Mycoctyes.” Biochem. Biophys. Res. Comm., vol. 244, 1998, pp. 275-279.
Ayers, G.M., et al.;Amiodarone Instilled Into the Canine Pericardial Sac Migrates Transmurally to Produce Electrophysiologic Effects and Suppress Atrial Fibrillation; Journal of Cardiovascular Electrophysiology; vol. 7, No. 8; Aug. 1996; 713-721.
Lamanna, C., et al.;Cardiac Effects of Botulinal Toxin; Arc. Int. Pharmacodyn.; 1988; vol. 293; 69-83.
Lamanna, C.;Thoughts on Action of Botulinum Toxin Suggested by Reversibility of Heart Effects; Botulinum and Tetanus Neurotoxins(edited by Dasgupta, B.R.); 1993 Plenum Press; 333-335.
McDermott, D.A., et al.;Use of an Indwelling Catheter for Examining Cardiovascular Responses to Pericardial Administration of Bradykinin in Rat; Cardiovascular Research; 1995; vol. 30; 39-46.
Sauviat, M.-P.,: “Effect of Neurotoxins on The Electrical and Mechanical Activity of Heart Muscle.”, Comptes Rendus Des Seances De La Societe De Biolobie Et De Ses Filiales., vol. 191, 1997, pp. 451-471.
Simonsen, U., et al.,Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs, Pflugers Arch—Eur J. Physiol (1999) 438:177-186.
Allergan Inc.
Brumback Brenda
Bunner Bridget E.
Hollrigel Greg S.
Stout, Uxa Buyan & Mullins, LLP
LandOfFree
Intrapericardial botulinum toxin treatment for bradycardia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Intrapericardial botulinum toxin treatment for bradycardia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intrapericardial botulinum toxin treatment for bradycardia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3465771