Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-03-07
1992-08-11
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514300, 514303, 546 82, 546119, 546121, A61K 3144, C07D47100
Patent
active
051378930
ABSTRACT:
The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is benefical. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbances (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
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Fludzinski et al. Inadzoles as Indole Bioesters J. Med. Chem. 30 No. 9 1535-7 Apr. 1987.
Becker Daniel P.
Flynn Daniel L.
Moormann Alan E.
Nosal Roger
Villamil Clara I.
Dentz Bernard
G. D. Searle & Co.
Matukaitis Paul D.
Williams Roger A.
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