Glycopeptide carboxy-saccharide derivatives

Details Glycopeptide carboxy-saccharide derivatives Glycopeptide carboxy-saccharide derivatives

2005-06-07

2005-06-07

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S322000

Reexamination Certificate

active

06903070

ABSTRACT:
Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

REFERENCES:
patent: 4643987 (1987-02-01), Nagarajan et al.
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 4727064 (1988-02-01), Pitha
patent: 4983586 (1991-01-01), Bodor
patent: 5024998 (1991-06-01), Bodor
patent: 5591714 (1997-01-01), Nagarajan et al.
patent: 5602112 (1997-02-01), Rubinfeld
patent: 5750509 (1998-05-01), Malabarba et al.
patent: 5840684 (1998-11-01), Cooper et al.
patent: 5916873 (1999-06-01), Cooper et al.
patent: 6392012 (2002-05-01), Judice et al.
patent: 6444786 (2002-09-01), Judice et al.
patent: 6620781 (2003-09-01), Linsell et al.
patent: 6770621 (2004-08-01), Linsell et al.
patent: 2002/0055464 (2002-05-01), Linsell et al.
patent: 0 667 353 (1995-08-01), None
patent: 0 816 378 (1998-01-01), None
patent: WO 94/12217 (1994-06-01), None
patent: WO 00/04044 (2000-01-01), None
patent: WO 00/39156 (2000-07-01), None
patent: WO 00/54751 (2000-09-01), None
patent: WO 00/59528 (2000-10-01), None
patent: WO 01/83520 (2001-11-01), None
patent: WO 01/97851 (2001-12-01), None
patent: WO 01/98326 (2001-12-01), None
patent: WO 01/98327 (2001-12-01), None
patent: WO 01/98328 (2001-12-01), None
patent: WO 01/98329 (2001-12-01), None
Allen et al., “The Role of Hydrophobic Side Chains as Determinants of Antibacterial Activity of Semisynthetic Glycopeptide Antibiotics”, The Journal of Antibiotics, vol. 50, No. 8, pp 677-684 (1997).
Ge et al., “Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding D-Ala-D-Ala”, Science, vol. 284, pp 507-511 (1999).
Nagarajan et al., “Synthesis and Antibacterial Evaluation of N-Alkyl Vancomycins”, The Journal of Antibiotics, vol. XLII, No. 1, pp 63-72 (1989).
Nicolaou et al., “Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics”, Angew. Chem. Int. Ed., vol. 38, pp 2097-2152 (1999).
Pavlov et al., “A New Type of Chemical Modification of Glycopeptides Antibiotics: Aminomethylated Derivatives of Eremomycin and Their Antibacterial Activity”, The Journal of Antibiotics, vol. 50, No. 6, pp 509-513 (1997).
Pavlov et al., “Chemical Modification of Glycopeptide Antibiotics”, Russian Journal of Bioorganic Chemistry, vol. 24, No. 9, pp 570-587 (1998).
Pavlov et al., “Mono and Double Modified Teicoplanin Aglycon Derivatives on the Amino Acid No. 7; Structure-activity Relationship”, The Journal of Antibiotics, vol. 51, No. 1, pp 73-78 (1998).
Zhang et al., “A review of recent applications of cyclodextrins for drug discovery”, Expert Opinion on Therapeutics Patents, vol. 9, No. 12, 21 pages (1999).

Affiliated with

Also associated with

Rating

Glycopeptide carboxy-saccharide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glycopeptide carboxy-saccharide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycopeptide carboxy-saccharide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3464108