Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-07-28
1992-08-11
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3740
Patent
active
051378710
ABSTRACT:
Administration of a Corticotropin-Releasing Factor (or a salt of analog thereof) decreases the leakage of blood components into brain tissue produced by various adverse medical conditions and reduces bleeding when muscle tissues are cut and handled, such as in plastic and reconstructive surgery. A method of treating a patient for injury to or disease of the brain, central nervous system, or musculature in which edema is a factor comprises administering to the patient a Corticotropin-Releasing Factor (or salt or analog) in an amount effective to decrease vascular permeability in the injured or diseased brain, nervous system tissue or musculature, and thereby to reduce edema. Administration in accordance with the method can be about two hours before surgery, or can be up to three days after injury.
REFERENCES:
patent: 3980778 (1976-09-01), Ayer et al.
patent: 4404198 (1983-09-01), Kelley
patent: 4415558 (1983-11-01), Vale, Jr. et al.
patent: 4489163 (1984-12-01), Rivier et al.
patent: 4517181 (1985-05-01), Ling et al.
patent: 4528189 (1985-07-01), Lederis et al.
patent: 4533654 (1985-08-01), Lederis et al.
patent: 4579844 (1986-04-01), Rovee et al.
patent: 4594329 (1986-06-01), Vale, Jr. et al.
patent: 4605642 (1986-08-01), Rivier et al.
patent: 4801612 (1989-01-01), Wei et al
Chan, et al., "Phospholipid Degradation and Edema Development in Cold-Injured Rat Brain", 1983, pp. 329-337, Brain Research, vol. 277, No. 2.
Esch, et al., "Isolation and Characterization of the Bovine Hypothalamic Corticotropin-Releasing Factor", 1984, pp. 899-905, Biochemical and Biophysical Research Communications, vol. 122, No. 3.
Ling, et al., "Isolation and Characterization of Caprine Corticotropin-Releasing Factor", 1984, pp. 1218-1224, Biochemical and Biophysical Research Factor, vol. 122, No. 3.
Melchiorri, et al., "Action of Sauvagine on the Mesenteric Vascular Bed of the Dog", 1981, pp. 1-13, Regulatory Peptides Elsevier/North-Holland Biomedical Press.
Patthy, et al., "Isolation and amino acid sequence of corticotropin-releasing factor from pig hypothalami", 1985, pp. 8762-8766, Proceedings of the Academy of Sciences, vol. 82, No. 24.
Pinckard, et al., "Platelet-Activating Factors", 1988, pp. 139-167, Inflammation: Basic Principles and Clinical Correlates, Raven Press, New York.
Stern, et al., "Ibuprofen in the Treatment of UV-B-Induced Inflammation", 1985, pp. 508-512, Archives of Dermatology, vol. 121, No. 4.
Lee Lester L.
Regents of the University of California
LandOfFree
Treatment to reduce edema for brain and musculature injuries does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment to reduce edema for brain and musculature injuries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment to reduce edema for brain and musculature injuries will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-346371