Surgery – Radioactive substance applied to body for therapy
Reexamination Certificate
2005-10-18
2005-10-18
Hindenburg, Max F. (Department: 3736)
Surgery
Radioactive substance applied to body for therapy
C977S726000
Reexamination Certificate
active
06955639
ABSTRACT:
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
REFERENCES:
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 6001054 (1999-12-01), Regulla et al.
patent: 6165440 (2000-12-01), Esenaliev
patent: 6369206 (2002-04-01), Leone et al.
patent: 6530944 (2003-03-01), West et al.
patent: 6645464 (2003-11-01), Hainfeld
patent: WO 00/06244 (2000-02-01), None
Manuel H. Castillo, et. al., “Effects of Radiotherapy on Mandibular Reconstruction Plates”,The American Journal of Surgery, vol. 156, pp. 261-263, (1988).
D. F. Regulla, et. al., “Physical and Biological Interface Dose Effects in Tissue due to X-Ray Induced Release of Secondary Radiation from Metallic Gold Surfaces”,Radiation Research, vol. 150, pp. 92-100, (1998).
Indra J. Das, et al., “Backscatter dose perturbation in kilovoltage photon beams at high atomic number interfaces”,Medical Physics, vol. 22, No. 6, pp. 767-773, (1995).
D. M. Herold, et. al. “Gold microspheres: a selective technique for producing biologically effective dose enhancement”,International Journal of Radiation Biology, vol. 76, No. 10, pp. 1357-1364, (2000).
Hiromichi Matsudaira, et. al., “Iodine Contrast Medium Sensitizes Cultured Mammalian Cells to X Rays but not to Y Rays”,Radiation Research, vol. 84, pp. 144-148, (1980).
Hainfeld James F.
Slatkin Daniel N.
Hindenburg Max F.
Nanoprobes, Inc.
Scully Scott Murphy & Presser
Veniaminov Nikita R.
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