Preparation of quinapril hydrochloride

Details Preparation of quinapril hydrochloride Preparation of quinapril hydrochloride

2005-02-22

2005-02-22

Owens, Amelia A. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06858735

ABSTRACT:
Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester to yield quinapril tert-butyl ester, which is subsequently reacted with an acid to yield quinapril or an acid addition salt of quinapril.

REFERENCES:
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4686295 (1987-08-01), Youssefyeh et al.
patent: 4761479 (1988-08-01), Goel et al.
patent: 6541635 (2003-04-01), Yu -Lian et al.
patent: 0049605 (1982-04-01), None
patent: 0 065 301 (1982-11-01), None
patent: 0 285 992 (1988-10-01), None
patent: 0 992 495 (2000-04-01), None
patent: 2 095 252 (1982-09-01), None
patent: WO 200218321 (2002-03-01), None
patent: WO 2004054980 (2004-07-01), None
Kluthchko et al., “Synthesis of Novel Angiotensin Converting Enzyme Inhibitor Quinapril and RElated Compounds. A Divergence of Structure-Activity Relationships for Non-Sulfhydryl and Sulfhydryl Types,” J.Med.Chem. vol. 29, p. 1953 (1986).

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